User profiles for Andreas Keller

Andreas Keller

Professor for Clinical Bioinformatics, Center for Bioinformatics, Saarland Informatics Campus
Verified email at ccb.uni-saarland.de
Cited by 26803

Humans can discriminate more than 1 trillion olfactory stimuli

C Bushdid, MO Magnasco, LB Vosshall, A Keller - Science, 2014 - science.org
Humans can discriminate several million different colors and almost half a million different
tones, but the number of discriminable olfactory stimuli remains unknown. The lay and …

[HTML][HTML] Dysregulation of brain and choroid plexus cell types in severe COVID-19

…, I Cobos, N Ludwig, WJ Schulz-Schaeffer, A Keller… - Nature, 2021 - nature.com
Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of
COVID-19 can suffer neurological symptoms 1, 2, 3. However, an unbiased understanding …

Genetic variation in a human odorant receptor alters odour perception

A Keller, H Zhuang, Q Chi, LB Vosshall, H Matsunami - Nature, 2007 - nature.com
Human olfactory perception differs enormously between individuals, with large reported
perceptual variations in the intensity and pleasantness of a given odour. For instance, …

[HTML][HTML] Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls

A Keller, P Leidinger, J Lange, A Borries, H Schroers… - PloS one, 2009 - journals.plos.org
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous
system, which is heterogenous with respect to clinical manifestations and response to …

The missense of smell: functional variability in the human odorant receptor repertoire

JD Mainland, A Keller, YR Li, T Zhou, C Trimmer… - Nature …, 2014 - nature.com
Humans have ∼400 intact odorant receptors, but each individual has a unique set of genetic
variations that lead to variation in olfactory perception. We used a heterologous assay to …

[PDF][PDF] Severe COVID-19 is marked by a dysregulated myeloid cell compartment

…, S Janssen, J Kalinowski, R Kallies, B Kehr, A Keller… - Cell, 2020 - cell.com
Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however,
a subset of patients progress to severe disease and respiratory failure. The mechanism …

[HTML][HTML] Swarm learning for decentralized and confidential clinical machine learning

…, J Nattermann, D Skowasch, I Kurth, A Keller… - Nature, 2021 - nature.com
Fast and reliable detection of patients with severe and heterogeneous illnesses is a major
goal of precision medicine 1 , 2 . Patients with leukaemia can be identified using machine …

[HTML][HTML] A human brain vascular atlas reveals diverse mediators of Alzheimer's risk

…, P Chu, JA Siegenthaler, MW McNerney, A Keller… - Nature, 2022 - nature.com
The human brain vasculature is of great medical importance: its dysfunction causes disability
and death 1 , and the specialized structure it forms—the blood–brain barrier—impedes the …

Distribution of miRNA expression across human tissues

…, B Meder, C Stähler, E Meese, A Keller - Nucleic acids …, 2016 - academic.oup.com
We present a human miRNA tissue atlas by determining the abundance of 1997 miRNAs in
61 tissue biopsies of different organs from two individuals collected post-mortem. One …

[HTML][HTML] Emerging concepts of miRNA therapeutics: from cells to clinic

C Diener, A Keller, E Meese - Trends in Genetics, 2022 - cell.com
MicroRNAs (miRNAs) are very powerful genetic regulators, as evidenced by the fact that a
single miRNA can direct entire cellular pathways via interacting with a broad spectrum of …