Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis

…, W Seeger, TE Weaver, A Guenther - American journal of …, 2008 - atsjournals.org
Rationale: The molecular pathomechanisms underlying idiopathic pulmonary fibrosis (IPF)
are elusive, but chronic epithelial injury has recently been suggested as key event. Objectives…

Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats

…, N Weissmann, F Rose, A Guenther… - American journal of …, 2004 - atsjournals.org
Sildenafil, a phosphodiesterase 5 inhibitor, is currently under investigation for therapy of
pulmonary hypertension. This study was designed to investigate chronic effects of sildenafil in …

[HTML][HTML] The European IPF registry (eurIPFreg): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis

A Guenther, E Krauss, S Tello, J Wagner, B Paul… - Respiratory …, 2018 - Springer
Background Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing
epidemiological data and biomaterials for translational research. Methods The registry …

Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung

…, RE Morty, I Henneke, A Guenther… - Blood, The Journal …, 2009 - ashpublications.org
Cell surface–associated proteolysis plays a crucial role in the migration of mononuclear
phagocytes to sites of inflammation. The glycolytic enzyme enolase-1 (ENO-1) binds …

Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis

…, SE Wert, M Dehoux, B Zweytick, A Guenther… - Thorax, 2011 - thorax.bmj.com
Background Bronchiolisation of distal airspaces is an unexplained feature of idiopathic
pulmonary fibrosis (IPF). The authors sought to identify mechanisms driving the differentiation of …

Panobinostat plus bortezomib and dexamethasone in previously treated multiple myeloma: outcomes by prior treatment

…, WW Jedrzejczak, A Guenther… - Blood, The Journal …, 2016 - ashpublications.org
Panobinostat is a potent pan-deacetylase inhibitor that affects the growth and survival of
multiple myeloma (MM) cells through alteration of epigenetic mechanisms and protein …

Increased extracellular vesicles mediate WNT5A signaling in idiopathic pulmonary fibrosis

…, M Lindner, W Gesierich, A Guenther… - American journal of …, 2018 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease characterized by lung
epithelial cell injury, increased (myo)fibroblast activation, and extracellular matrix deposition. …

[PDF][PDF] Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma

R Burger, A Guenther, F Bakker… - The Hematology …, 2001 - researchgate.net
Plasmacytoma is a clonal B-cell neoplasm in which malignant plasma cells accumulate in
the bone marrow. Treatment of the disease has been difficult and the fiveyear survival rate for …

Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice

…, PH Weinreb, SM Violette, A Guenther… - American journal of …, 2009 - atsjournals.org
Rationale: Fibroblast growth factor-10 (FGF10) controls survival, proliferation, and differentiation
of distal-alveolar epithelial progenitor cells during lung development. Objectives: To test …

Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis

…, L Fink, W Seeger, OH Krämer, A Guenther - Thorax, 2015 - thorax.bmj.com
Background Activation and differentiation of fibroblasts into contractile protein-expressing
myofibroblasts and their acquired apoptosis-resistant phenotype are critical factors towards the …