Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis
…, W Seeger, TE Weaver, A Guenther - American journal of …, 2008 - atsjournals.org
Rationale: The molecular pathomechanisms underlying idiopathic pulmonary fibrosis (IPF)
are elusive, but chronic epithelial injury has recently been suggested as key event. Objectives…
are elusive, but chronic epithelial injury has recently been suggested as key event. Objectives…
Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats
…, N Weissmann, F Rose, A Guenther… - American journal of …, 2004 - atsjournals.org
Sildenafil, a phosphodiesterase 5 inhibitor, is currently under investigation for therapy of
pulmonary hypertension. This study was designed to investigate chronic effects of sildenafil in …
pulmonary hypertension. This study was designed to investigate chronic effects of sildenafil in …
[HTML][HTML] The European IPF registry (eurIPFreg): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis
A Guenther, E Krauss, S Tello, J Wagner, B Paul… - Respiratory …, 2018 - Springer
Background Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing
epidemiological data and biomaterials for translational research. Methods The registry …
epidemiological data and biomaterials for translational research. Methods The registry …
Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung
…, RE Morty, I Henneke, A Guenther… - Blood, The Journal …, 2009 - ashpublications.org
Cell surface–associated proteolysis plays a crucial role in the migration of mononuclear
phagocytes to sites of inflammation. The glycolytic enzyme enolase-1 (ENO-1) binds …
phagocytes to sites of inflammation. The glycolytic enzyme enolase-1 (ENO-1) binds …
Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis
…, SE Wert, M Dehoux, B Zweytick, A Guenther… - Thorax, 2011 - thorax.bmj.com
Background Bronchiolisation of distal airspaces is an unexplained feature of idiopathic
pulmonary fibrosis (IPF). The authors sought to identify mechanisms driving the differentiation of …
pulmonary fibrosis (IPF). The authors sought to identify mechanisms driving the differentiation of …
Panobinostat plus bortezomib and dexamethasone in previously treated multiple myeloma: outcomes by prior treatment
…, WW Jedrzejczak, A Guenther… - Blood, The Journal …, 2016 - ashpublications.org
Panobinostat is a potent pan-deacetylase inhibitor that affects the growth and survival of
multiple myeloma (MM) cells through alteration of epigenetic mechanisms and protein …
multiple myeloma (MM) cells through alteration of epigenetic mechanisms and protein …
Increased extracellular vesicles mediate WNT5A signaling in idiopathic pulmonary fibrosis
…, M Lindner, W Gesierich, A Guenther… - American journal of …, 2018 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease characterized by lung
epithelial cell injury, increased (myo)fibroblast activation, and extracellular matrix deposition. …
epithelial cell injury, increased (myo)fibroblast activation, and extracellular matrix deposition. …
[PDF][PDF] Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma
R Burger, A Guenther, F Bakker… - The Hematology …, 2001 - researchgate.net
Plasmacytoma is a clonal B-cell neoplasm in which malignant plasma cells accumulate in
the bone marrow. Treatment of the disease has been difficult and the fiveyear survival rate for …
the bone marrow. Treatment of the disease has been difficult and the fiveyear survival rate for …
Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice
…, PH Weinreb, SM Violette, A Guenther… - American journal of …, 2009 - atsjournals.org
Rationale: Fibroblast growth factor-10 (FGF10) controls survival, proliferation, and differentiation
of distal-alveolar epithelial progenitor cells during lung development. Objectives: To test …
of distal-alveolar epithelial progenitor cells during lung development. Objectives: To test …
Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis
…, L Fink, W Seeger, OH Krämer, A Guenther - Thorax, 2015 - thorax.bmj.com
Background Activation and differentiation of fibroblasts into contractile protein-expressing
myofibroblasts and their acquired apoptosis-resistant phenotype are critical factors towards the …
myofibroblasts and their acquired apoptosis-resistant phenotype are critical factors towards the …