[HTML][HTML] The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants

…, A Bosshart, C Iss, V Calabro, A Cornelius… - Nature …, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
with potential resistance to existing drugs emphasizes the need for new therapeutic …

Design and characterization of MP0250, a tri-specific anti-HGF/anti-VEGF DARPin® drug candidate

HK Binz, TR Bakker, DJ Phillips, A Cornelius, C Zitt… - MAbs, 2017 - Taylor & Francis
MP0250 is a multi-domain drug candidate currently being tested in clinical trials for the treatment
of cancer. It comprises one anti-vascular endothelial growth factor-A (VEGF-A), one anti-…

Highly potent anti-SARS-CoV-2 multi-DARPin therapeutic candidates

…, M Paladino, T Hospodarsch, A Neculcea, A Cornelius… - Biorxiv, 2020 - biorxiv.org
Globally accessible preventive and therapeutic molecules against SARS-CoV-2 are urgently
needed. DARPin molecules are an emerging class of novel therapeutics based on naturally …

[HTML][HTML] Transport of Designed Ankyrin Repeat Proteins through reconstituted human bronchial epithelia and protection against SARS-CoV-2

L Künzi, S Ryter, A Cornelius, Z Leni, N Baumlin… - Scientific Reports, 2023 - nature.com
Clinical studies have proven antiviral effectiveness of treatment with a Designed Ankyrin
Repeat Protein (DARPin) specific against the spike protein of severe acute respiratory …

Incivility begets incivility: Understanding the relationship between experienced and enacted incivility with customers over time

CL Thomas, LU Johnson, AM Cornelius… - Journal of Business and …, 2022 - Springer
Workplace incivility, characterized by low-intensity, ambiguous, and rude interpersonal
interactions, is typically conceptualized with an events-based perspective (Andersson & Pearson, …

[HTML][HTML] MP0250, a VEGF and HGF neutralizing DARPin® molecule shows high anti-tumor efficacy in mouse xenograft and patient-derived tumor models

U Fiedler, S Ekawardhani, A Cornelius, P Gilboy… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Background The VEGF/VEGFR and the HGF/cMET pathways are key mediators of the interplay
of tumor cells and their microenvironment. However, inhibition of VEGF has been shown …

Ensovibep, a novel trispecific DARPin candidate that protects against SARS-CoV-2 variants

…, N Liechti, A Bosshart, C Iss, V Calabro, A Cornelius… - bioRxiv, 2021 - biorxiv.org
The SARS-CoV-2 virus responsible for the COVID-19 pandemic has so far infected more than
160 million people globally, and continues to undergo genomic evolution. Emerging SARS…

Multi-specific DARPin (R) therapeutics demonstrate very high potency against mutated SARS-CoV-2 variants in vitro

…, N Liechti, A Bosshart, C Iss, V Calabro, A Cornelius… - 2021 - pesquisa.bvsalud.org
… Hurdiss; Marcel Walser; Francesca Malvezzi; Jennifer Mayor; Sarah Ryter; Hector Moreno;
Nicole Liechti; Andreas Bosshart; Chloe Iss; Valerie Calabro; Andreas Cornelius; Tanja …

Remote work: More nuance and unknowns than broad generalizations.

…, KN Lavigne, RJ Koziel, AM Cornelius - Consulting Psychology …, 2023 - psycnet.apa.org
Drawing on the existing integrative evidence (eg, reviews, meta-analyses, theory articles)
from 2016 to 2022, the current review synthesizes the remote work literature and identifies …

COVID-19 Preparedness, Stressors, and Data-Driven Solutions for Healthcare Workers at a Regional Rural-Urban Hospital System: A Longitudinal Total Worker …

LA Jaegers, R McAndrew, A Cornelius… - … Health & Safety, 2024 - journals.sagepub.com
Background: During the COVID-19 pandemic in the United States, healthcare workers were
devastated by the insufficient preparedness to respond to their patients’ and personal health …