Environmental allergens are an important cause of asthma and can contribute to loss of
asthma control and exacerbations. Allergen inhalation challenge has been a useful clinical …

Asthma is characterized by discordant responses among cells of the adaptive and innate
immune systems. This interplay involves a complex pattern of cytokine‐driven processes …

Aeroallergens inhaled into allergic asthmatic airways initiate type 2 inflammation, including
production of the cytokines IL-4 and IL-13 known to promote maturation of IgE-producing B …

Rationale: The American Thoracic Society guidelines for methacholine testing for the diagnosis
of asthma recommends the 2-minute tidal breathing protocol with the Wright nebulizer, …

Current asthma treatments are effective for the majority of patients with mild-to-moderate
disease. However, in those with more severe refractory asthma, agents other than inhaled …

Rationale: Group 2 innate lymphoid cells (ILC2), a major source of type 2 cytokines, initiate
eosinophilic inflammatory responses in murine models of asthma. Objectives: To investigate …

Background: Decreased physical capacity and increased systemic inflammatory response
are frequently observed in patients with chronic obstructive pulmonary disease (COPD). The …

Background: Previous murine models have demonstrated interleukin (IL)-33 to be an important
mediator of type-2 inflammation and to promote airway hyperresponsiveness in allergic …

Rationale: Dendritic cells (DCs) are antigen-presenting cells essential for the initiation of T-cell
responses. Allergen inhalation increases the number of airway DCs and the release of …

Allergic asthma is a chronic inflammatory disease of the airways that in some patients is
characterized by airway eosinophilia. IL-33 and thymic stromal lymphopoietin (TSLP) are key …