Nasal nitric oxide measurement in children for the diagnosis of primary ciliary dyskinesia: European Respiratory Society technical standard

…, SD Davis, E Haarman, AL Harris… - European …, 2023 - Eur Respiratory Soc
Nasal nitric oxide (nNO) is extremely low in most people with primary ciliary dyskinesia (PCD)
and its measurement is an important contributor to making the diagnosis. Existing …

An international survey on nasal nitric oxide measurement practices for the diagnosis of primary ciliary dyskinesia

N Beydon, T Ferkol, AL Harris, M Colas… - ERJ open …, 2022 - Eur Respiratory Soc
Nasal nitric oxide (nNO) measurements are used in the assessment of patients suspected of
having primary ciliary dyskinesia (PCD), but recommendations for performing such …

The accuracy of nasal nitric oxide testing in PCD diagnostics is population specific

S Collins, L Behan, H Evans, P Goggin, AL Harris… - 2015 - Eur Respiratory Soc
Background: Nasal nitric oxide (nNO) is usually low in primary ciliary dyskinesia (PCD) and
measurement is part of a complex diagnostic work-up. Previous research has failed to define …

Genetic and environmental perturbations lead to regulatory decoherence

A Lea, M Subramaniam, A Ko, T Lehtimäki… - Elife, 2019 - elifesciences.org
10.7554/eLife.40538.001 Correlation among traits is a fundamental feature of biological
systems that remains difficult to study. To address this problem, we developed a flexible …

Developmental plasticity: bridging research in evolution and human health

AJ Lea, J Tung, EA Archie… - Evolution, medicine, and …, 2017 - academic.oup.com
Early life experiences can have profound and persistent effects on traits expressed throughout
the life course, with consequences for later life behavior, disease risk, and mortality rates. …

High social status males experience accelerated epigenetic aging in wild baboons

JA Anderson, RA Johnston, AJ Lea, FA Campos… - Elife, 2021 - elifesciences.org
Aging, for virtually all life, is inescapable. However, within populations, biological aging
rates vary. Understanding sources of variation in this process is central to understanding the …

[PDF][PDF] Genome-wide evidence reveals that African and Eurasian golden jackals are distinct species

KP Koepfli, J Pollinger, R Godinho, J Robinson, A Lea… - Current biology, 2015 - cell.com
The golden jackal of Africa (Canis aureus) has long been considered a conspecific of jackals
distributed throughout Eurasia, with the nearest source populations in the Middle East. …

Disease and freeways drive genetic change in urban bobcat populations

LEK Serieys, A Lea, JP Pollinger… - Evolutionary …, 2015 - Wiley Online Library
Urbanization profoundly impacts animal populations by causing isolation, increased
susceptibility to disease, and exposure to toxicants. Genetic effects include reduced effective …

Genome-wide quantification of the effects of DNA methylation on human gene regulation

AJ Lea, CM Vockley, RA Johnston, CA Del Carpio… - elife, 2018 - elifesciences.org
10.7554/eLife.37513.001 Changes in DNA methylation are involved in development, disease,
and the response to environmental conditions. However, not all regulatory elements are …

Heritable victimization and the benefits of agonistic relationships

AJ Lea, DT Blumstein, TW Wey… - Proceedings of the …, 2010 - National Acad Sciences
Here, we present estimates of heritability and selection on network traits in a single
population, allowing us to address the evolutionary potential of social behavior and the poorly …