Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.

…, DH Henkelman, AC Eaves, CJ Eaves - Proceedings of the …, 1990 - National Acad Sciences
A major goal of current hematopoiesis research is to develop in vitro methods suitable for
the measurement and characterization of stem cells with long-term in vivo repopulating …

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

HJ Sutherland, CJ Eaves, AC Eaves, W Dragowska… - 1989 - ashpublications.org
To develop a purification strategy for isolating the most primitive hematopoietic stem cells
present in normal human marrow we have combined cell separation techniques with an assay …

Three stages of erythropoietic progenitor cell differentiation distinguished by a number of physical and biologic properties

CJ Gregory, AC Eaves - 1978 - ashpublications.org
Previous studies have shown that erythroid precursors at sequential stages of differentiation
along the red cell pathway can be distinguished by differences in the size and maturation …

Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.

…, PM Lansdorp, AC Eaves, CJ Eaves - Proceedings of the …, 1990 - National Acad Sciences
Although hematopoiesis is known to originate in a population of very primitive cells with both
lymphopoietic and myelopoietic potential, a procedure for enumerating such cells has to …

Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia

…, X Jiang, C Eaves, A Eaves - Blood, The Journal of the …, 1999 - ashpublications.org
Chronic myeloid leukemia (CML) is characterized by an increased proliferative activity of
the leukemic progenitors that produce an elevated number of mature granulocytes. …

Human marrow cells capable of erythropoietic differentiation in vitro: definition of three erythroid colony responses

CJ Gregory, AC Eaves - 1977 - ashpublications.org
A systematic study has been undertaken to analyze the spectrum of erythropoietic colonies
obtained in cultures of human marrow cells plated in methyl cellulose. Colonies were …

Identification and isolation of hematopoietic stem cells

AW Wognum, AC Eaves, TE Thomas - Archives of medical research, 2003 - Elsevier
Hematopoietic stem cells (HSCs) are defined by their ability to repopulate all of the
hematopoietic lineages in vivo and sustain the production of these cells for the life span of the …

Enumeration of neural stem and progenitor cells in the neural colony-forming cell assay

…, L Deleyrolle, RE Wagey, TE Thomas, AC Eaves… - Stem Cells, 2008 - academic.oup.com
Advancement in our understanding of the biology of adult stem cells and their therapeutic
potential relies heavily on meaningful functional assays that can identify and measure stem …

Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia

…, T Holyoake, A Eaves, C Eaves - Proceedings of the …, 1999 - National Acad Sciences
Primitive subsets of leukemic cells isolated by using fluorescence-activated cell sorting from
patients with newly diagnosed Ph + /BCR–ABL + chronic myeloid leukemia display an …

Prognostic implications of differences in telomere length between normal and malignant cells from patients with chronic myeloid leukemia measured by flow cytometry

…, M Schulzer, CJ Eaves, AC Eaves… - Blood, The Journal …, 2000 - ashpublications.org
Chronic myeloid leukemia (CML) is a clonal, multilineage myeloproliferative disorder
characterized by the Philadelphia chromosome (Ph) and a marked expansion of myeloid cells. …