Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)?

A Huertas, D Montani, L Savale… - European …, 2020 - Eur Respiratory Soc
Coronavirus disease 2019 (COVID-19) represents a public health crisis of pandemic
proportions. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the …

Inflammation in pulmonary arterial hypertension

LC Price, SJ Wort, F Perros, P Dorfmüller, A Huertas… - Chest, 2012 - Elsevier
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling
of the precapillary pulmonary arteries, with excessive proliferation of vascular cells. Although …

C-kit–positive cells accumulate in remodeled vessels of idiopathic pulmonary arterial hypertension

…, B Girerd, P Dorfmuller, LC Price, A Huertas… - American journal of …, 2011 - atsjournals.org
Rationale: C-kit + cells, including bone marrow (BM)–derived progenitors and mast cells,
may participate in vascular remodelling. Because recent studies suggest that c-kit may be a …

Pathogenesis of pulmonary arterial hypertension: lessons from cancer

…, C Sattler, A Seferian, A Huertas… - European …, 2013 - Eur Respiratory Soc
Although the causal pathomechanisms contributing to remodelling of the pulmonary vascular
bed in pulmonary arterial hypertension (PAH) are still unclear, several analogous features …

Increased pericyte coverage mediated by endothelial-derived fibroblast growth factor-2 and interleukin-6 is a source of smooth muscle–like cells in pulmonary …

N Ricard, L Tu, M Le Hiress, A Huertas, C Phan… - Circulation, 2014 - Am Heart Assoc
Background— Pericytes and their crosstalk with endothelial cells are critical for the
development of a functional microvasculature and vascular remodeling. It is also known that …

Proinflammatory signature of the dysfunctional endothelium in pulmonary hypertension. Role of the macrophage migration inhibitory factor/CD74 complex

…, F de Man, M Humbert, A Huertas… - American journal of …, 2015 - atsjournals.org
Rationale: Inflammation and endothelial dysfunction are considered two primary instigators
of pulmonary arterial hypertension (PAH). CD74 is a receptor for the proinflammatory …

Immune dysregulation and endothelial dysfunction in pulmonary arterial hypertension: a complex interplay

A Huertas, F Perros, L Tu, S Cohen-Kaminsky… - Circulation, 2014 - Am Heart Assoc
Huertas et al Immune/Endothelial Dysregulation in PAH 1333 comprise pulmonary transmural
inflammatory cell infiltrates with focal vessel wall necrosis and fibrinoid insudation, a …

New molecular targets of pulmonary vascular remodeling in pulmonary arterial hypertension: importance of endothelial communication

C Guignabert, L Tu, B Girerd, N Ricard, A Huertas… - Chest, 2015 - Elsevier
Pulmonary arterial hypertension (PAH) is a disorder in which mechanical obstruction of the
pulmonary vascular bed is largely responsible for the rise in mean pulmonary arterial …

Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases: highlights from basic research to therapy

A Huertas, C Guignabert, JA Barberà… - European …, 2018 - Eur Respiratory Soc
The European Respiratory Society (ERS) Research Seminar entitled “Pulmonary vascular
endothelium: orchestra conductor in respiratory diseases - highlights from basic research to …

[HTML][HTML] Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension

…, E Fadel, L Savale, A Huertas… - The Journal of …, 2018 - Am Soc Clin Investig
Pulmonary arterial hypertension (PAH) is characterized by a progressive accumulation of
pulmonary artery smooth muscle cells (PA-SMCs) in pulmonary arterioles leading to the …