User profiles for Alexis Labrada
Alexis LabradaR&D Director National Center Bioproducts (BIOCEN), Cuba Verified email at biocen.cu Cited by 893 |
[HTML][HTML] Adjuvants are key factors for the development of future vaccines: lessons from the Finlay adjuvant platform
…, E González, A Batista-Duharte, A Labrada… - Frontiers in …, 2013 - frontiersin.org
The development of effective vaccines against neglected diseases, especially those associated
with poverty and social deprivation, is urgently needed. Modern vaccine technologies …
with poverty and social deprivation, is urgently needed. Modern vaccine technologies …
[HTML][HTML] Endotoxin Exposure during Sensitization to Blomia tropicalis Allergens Shifts TH2 Immunity Towards a TH17-Mediated Airway Neutrophilic Inflammation …
Experimental evidence and epidemiological studies indicate that exposure to endotoxin
lipopolysaccharide (eLPS) or other TLR agonists prevent asthma. We have previously shown in …
lipopolysaccharide (eLPS) or other TLR agonists prevent asthma. We have previously shown in …
[HTML][HTML] Allergen micro-bead array for IgE detection: a feasibility study using allergenic molecules tested on a flexible multiplex flow cytometric immunoassay
Background Allergies represent the most prevalent non infective diseases worldwide.
Approaching IgE-mediated sensitizations improved much by adopting allergenic molecules …
Approaching IgE-mediated sensitizations improved much by adopting allergenic molecules …
[HTML][HTML] Allergen-specific immunotherapy with liposome containing CpG-ODN in murine model of asthma relies on MyD88 signaling in dendritic cells
…, FPB Nunes, MK De Siqueira, A Labrada… - Frontiers in …, 2020 - frontiersin.org
Changing the immune responses to allergens is the cornerstone of allergen immunotherapy.
Allergen-specific immunotherapy that consists of repeated administration of increasing …
Allergen-specific immunotherapy that consists of repeated administration of increasing …
[HTML][HTML] Identification of B Cell epitopes of blo t 13 allergen and cross-reactivity with human adipocytes and heart fatty acid binding Proteins
Cross-reactivity between allergens and human proteins could have a clinical impact in allergic
diseases. Blo t 13 is an allergen from the mite Blomia tropicalis, which belongs to the fatty …
diseases. Blo t 13 is an allergen from the mite Blomia tropicalis, which belongs to the fatty …
Protective effects of Surfacen® in allergen-induced asthma mice model
…, VS Rodríguez, W Alfonso, A Labrada - International …, 2022 - Elsevier
Airway obstruction with increased airway resistance in asthma, commonly caused by smooth
muscle constriction, mucosal edema and fluid secretion into the airway lumen, may partly …
muscle constriction, mucosal edema and fluid secretion into the airway lumen, may partly …
Monoclonal antibodies against Blo t 13, a recombinant allergen from Blomia tropicalis
M Labrada, K Uyema, M Sewer, A Labrada… - International archives of …, 2002 - karger.com
Background: The recombinant allergen of Blomia tropicalis, rBlo t 13, shows 11% of IgE
reactivity to sera from allergic patients. This allergen belongs to the fatty acid-binding protein …
reactivity to sera from allergic patients. This allergen belongs to the fatty acid-binding protein …
[PDF][PDF] Bacterial derived proteoliposome for allergy vaccines
One current approach in developing anti allergic vaccines is the use of potent adjuvants,
capable of inducing Th1 or T regulatory cells. Proteoliposomes (PL) could be a suitable …
capable of inducing Th1 or T regulatory cells. Proteoliposomes (PL) could be a suitable …
Modulation of the specific allergic response by mite allergens encapsulated into liposomes
Liposomes are non toxic and biodegradable lipid vesicles, which are safe and effective
adjuvants to induce Th1-skewed immune response. Therefore, the encapsulation of allergens …
adjuvants to induce Th1-skewed immune response. Therefore, the encapsulation of allergens …
[HTML][HTML] Immunogenicity of a novel anti-allergic vaccine based on house dust mite purified allergens and a combination adjuvant in a murine prophylactic model
…, M Lastre, O Perez, A Jacquet, A Labrada - Frontiers in …, 2022 - frontiersin.org
The outer-membrane-derived proteoliposome (PL) of Neisseria meningitidis has been
reported as a potent vaccine adjuvant, inducing a Th1-skewed response. This work aimed to …
reported as a potent vaccine adjuvant, inducing a Th1-skewed response. This work aimed to …