User profiles for Alexis Labrada

Alexis Labrada

R&D Director National Center Bioproducts (BIOCEN), Cuba
Verified email at biocen.cu
Cited by 893

[HTML][HTML] Adjuvants are key factors for the development of future vaccines: lessons from the Finlay adjuvant platform

…, E González, A Batista-Duharte, A Labrada… - Frontiers in …, 2013 - frontiersin.org
The development of effective vaccines against neglected diseases, especially those associated
with poverty and social deprivation, is urgently needed. Modern vaccine technologies …

[HTML][HTML] Endotoxin Exposure during Sensitization to Blomia tropicalis Allergens Shifts TH2 Immunity Towards a TH17-Mediated Airway Neutrophilic Inflammation …

…, A Sá-Nunes, E Florsheim, L Mirotti, A Labrada… - PloS one, 2013 - journals.plos.org
Experimental evidence and epidemiological studies indicate that exposure to endotoxin
lipopolysaccharide (eLPS) or other TLR agonists prevent asthma. We have previously shown in …

[HTML][HTML] Allergen micro-bead array for IgE detection: a feasibility study using allergenic molecules tested on a flexible multiplex flow cytometric immunoassay

…, L Tuppo, C Rafaiani, M Santoro, A Labrada… - PloS one, 2012 - journals.plos.org
Background Allergies represent the most prevalent non infective diseases worldwide.
Approaching IgE-mediated sensitizations improved much by adopting allergenic molecules …

[HTML][HTML] Allergen-specific immunotherapy with liposome containing CpG-ODN in murine model of asthma relies on MyD88 signaling in dendritic cells

…, FPB Nunes, MK De Siqueira, A Labrada… - Frontiers in …, 2020 - frontiersin.org
Changing the immune responses to allergens is the cornerstone of allergen immunotherapy.
Allergen-specific immunotherapy that consists of repeated administration of increasing …

[HTML][HTML] Identification of B Cell epitopes of blo t 13 allergen and cross-reactivity with human adipocytes and heart fatty acid binding Proteins

M Múnera, D Martínez, A Labrada, L Caraballo… - International journal of …, 2019 - mdpi.com
Cross-reactivity between allergens and human proteins could have a clinical impact in allergic
diseases. Blo t 13 is an allergen from the mite Blomia tropicalis, which belongs to the fatty …

Protective effects of Surfacen® in allergen-induced asthma mice model

…, VS Rodríguez, W Alfonso, A Labrada - International …, 2022 - Elsevier
Airway obstruction with increased airway resistance in asthma, commonly caused by smooth
muscle constriction, mucosal edema and fluid secretion into the airway lumen, may partly …

Monoclonal antibodies against Blo t 13, a recombinant allergen from Blomia tropicalis

M Labrada, K Uyema, M Sewer, A Labrada… - International archives of …, 2002 - karger.com
Background: The recombinant allergen of Blomia tropicalis, rBlo t 13, shows 11% of IgE
reactivity to sera from allergic patients. This allergen belongs to the fatty acid-binding protein …

[PDF][PDF] Bacterial derived proteoliposome for allergy vaccines

M Lastre, O Pérez, A Labrada, I Bidot, J Pérez… - Vaccine, 2006 - academia.edu
One current approach in developing anti allergic vaccines is the use of potent adjuvants,
capable of inducing Th1 or T regulatory cells. Proteoliposomes (PL) could be a suitable …

Modulation of the specific allergic response by mite allergens encapsulated into liposomes

…, V Bourg, C Alvarez, A Otero, M Russo, A Labrada… - Vaccine, 2006 - Elsevier
Liposomes are non toxic and biodegradable lipid vesicles, which are safe and effective
adjuvants to induce Th1-skewed immune response. Therefore, the encapsulation of allergens …

[HTML][HTML] Immunogenicity of a novel anti-allergic vaccine based on house dust mite purified allergens and a combination adjuvant in a murine prophylactic model

…, M Lastre, O Perez, A Jacquet, A Labrada - Frontiers in …, 2022 - frontiersin.org
The outer-membrane-derived proteoliposome (PL) of Neisseria meningitidis has been
reported as a potent vaccine adjuvant, inducing a Th1-skewed response. This work aimed to …