… If we consider the combination of DNA methylation and histone modification patterns, with
the possibility of paramutation as well (59), it would be highly surprising if epigenetics was not …

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

We have investigated the polymorphism in intron 2 of the interleukin-1 receptor antagonist
gene and identified two new alleles of the system. We have shown that the polymorphism is …

We analyzed genome-wide association data from 1,380 Europeans with early-onset and
morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers …

In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we
identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a …

Naturally occurring variation in gene copy number is increasingly recognized as a heritable
source of susceptibility to genetically complex diseases. Here we report strong association …

Context To design rational management regimes and identify novel therapeutic targets, it is
essential to understand the biological drivers of the current epidemic of obesity. This review …

Common copy number variations (CNVs) represent a significant source of genetic diversity,
yet their influence on phenotypic variability, including disease susceptibility, remains poorly …

Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability.
Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We …