Bile acids (BAs) are known to be important regulators of intestinal motility and epithelial fluid
and electrolyte transport. Over the past two decades, significant advances in identifying and …

Aim In nephrotic syndrome, aberrantly filtered plasminogen (plg) is converted to active
plasmin by tubular urokinase‐type plasminogen activator (uPA) and thought to lead to sodium …

Proteolytic activation of the epithelial sodium channel (ENaC) by aberrantly filtered serine
proteases is thought to contribute to renal sodium retention in nephrotic syndrome. However, …

Aim The serine protease prostasin (Prss8) is expressed in the distal tubule and stimulates
proteolytic activation of the epithelial sodium channel (ENaC) in co‐expression experiments in …

The epithelial sodium channel (ENaC) is a heterotrimer consisting of α-, β-, and γ-subunits.
Channel activation requires proteolytic release of inhibitory tracts from the extracellular …

The epithelial sodium channel (ENaC) is a member of the ENaC/degenerin ion channel
family, which also includes the bile acid-sensitive ion channel (BASIC). So far little is known …

Mice lacking connexin 30 (Cx30) display increased epithelial sodium channel (ENaC) activity
in the distal nephron and develop salt-sensitive hypertension. This indicates a functional …

Outer Medullary Collecting Duct (OMCD) principal cells are exposed to significant changes
of the extracellular osmolarity and thus the analysis of their regulatory volume decrease (RVD…

We recently demonstrated that bile acids, especially tauro-deoxycholic acid (t-DCA), modify
the function of the acid-sensing ion channel ASIC1a and other members of the epithelial …

Acid‐sensing ion channels ( ASIC s) are nonvoltage‐gated sodium channels transiently
activated by extracellular protons and belong to the epithelial sodium channel ( EN aC)/…