Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain

AM Horowitz, X Fan, G Bieri, LK Smith… - Science, 2020 - science.org
Reversing brain aging may be possible through systemic interventions such as exercise. We
found that administration of circulating blood factors in plasma from exercised aged mice …

[HTML][HTML] Platelet factors attenuate inflammation and rescue cognition in ageing

…, J Sucharov, R Misra, MKK Chui, G Bieri, AM Horowitz… - Nature, 2023 - nature.com
Identifying therapeutics to delay, and potentially reverse, age-related cognitive decline is
critical in light of the increased incidence of dementia-related disorders forecasted in the …

[HTML][HTML] The selective angiotensin II type 2 receptor agonist, compound 21, attenuates the progression of lung fibrosis and pulmonary hypertension in an experimental …

A Rathinasabapathy, A Horowitz, K Horton… - Frontiers in …, 2018 - frontiersin.org
Idiopathic Pulmonary Fibrosis (IPF) is a chronic lung disease characterized by scar formation
and respiratory insufficiency, which progressively leads to death. Pulmonary hypertension (…

Therapeutic potential of adipose stem cell‐derived conditioned medium against pulmonary hypertension and lung fibrosis

…, E Bruce, A Espejo, A Horowitz… - British Journal of …, 2016 - Wiley Online Library
Background and Purpose Pulmonary hypertension (PH) and pulmonary fibrosis (PF) are life
threatening cardiopulmonary diseases. Existing pharmacological interventions have failed …

[HTML][HTML] Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease

AM Horowitz, SA Villeda - F1000Research, 2017 - ncbi.nlm.nih.gov
Neurodegenerative diseases are a devastating group of conditions that cause progressive
loss of neuronal integrity, affecting cognitive and motor functioning in an ever-increasing …

The aged hematopoietic system promotes hippocampal‐dependent cognitive decline

LK Smith, E Verovskaya, G Bieri, AM Horowitz… - Aging …, 2020 - Wiley Online Library
The aged systemic milieu promotes cellular and cognitive impairments in the hippocampus.
Here, we report that aging of the hematopoietic system directly contributes to the pro‐aging …

Platelet factors attenuate inflammation and rescue cognition in ageing.

A Horowitz, L Smith, K Encabo, I Tenggara… - Nature, 2023 - escholarship.org
Identifying therapeutics to delay, and potentially reverse, age-related cognitive decline is
critical in light of the increased incidence of dementia-related disorders forecasted in the …

C21, a nonpeptide angiotensin II type 2 receptor agonist attenuates lung fibrosis and associated cardiac dysfunction

A Rathinasabapathy, A Horowitz, K Horton… - 2015 - Eur Respiratory Soc
Pulmonary fibrosis (PF) is a fatal disease characterized by scarring of the lung tissue. A
dysregulated renin angiotensin system (RAS) has been implicated in the pathology of PF. …

[PDF][PDF] Platelets give a running start to adult hippocampal neurogenesis

AB Schroer, AM Horowitz, SA Villeda - Stem cell reports, 2019 - cell.com
Exercise boosts neural stem and progenitor cell proliferation and differentiation in the
dentate gyrus region of the hippocampus. In this issue of Stem Cell Reports, Leiter et al. (2019) …

C21, an AT2R agonist, arrests the progression of bleomycin‐induced pulmonary fibrosis and associated cardiac dysfunctions

A Rathinasabapathy, A Horowitz, A Kumar… - The FASEB …, 2016 - Wiley Online Library
Pulmonary Fibrosis (PF) is a chronic, lethal interstitial lung disease with a median survival of
less than 3 years after the onset of disease. PF related mortality necessitates the …