Purpose: Epidermal growth factor receptor (EGFR) is commonly overexpressed in lung cancer.
Cetuximab is a chimeric mouse-human antibody targeted against EGFR. Compared with …

Osteopetrotic (op/op) mice have a severe deficiency of osteoclasts, monocytes, and peritoneal
macrophages because of a defect in the production of functional macrophage colony-…

Chronic airways diseases, including asthma, are associated with an increased airway
smooth muscle (ASM) mass, which may contribute to chronic airway hyperresponsiveness. …

Objective: To examine the role of heme oxygenase-1 (HO-1) induction in the recovery of renal
function in rats with ischemic acute renal failure. Design: Randomized, masked, controlled …

Lung cancer is one of the most aggressive tumour types. Targeted therapies stratified by
oncogenic drivers have substantially improved therapeutic outcomes in patients with non-small-…

Recently, IL-17A has been shown to be expressed in higher levels in respiratory secretions
from asthmatics and correlated with airway hyperresponsiveness. Although these studies …

Background: Severe wind storms during spring in East Asia, called Asian dust storms (ADS),
have been assessed in the past for their effect on health in Asian countries. Our objective …

Although eosinophilic inflammation is characteristic of asthma pathogenesis, neutrophilic
inflammation is also marked, and eosinophils and neutrophils can coexist in some cases. …

Background: We explored whether the use of deep learning to model combinations of
symptom-physical signs and objective tests, such as lung function tests and the bronchial …

Discussion The most common acquired resistance mechanism after initial EGFR TKI treatment
is the secondary T790M mutation of EGFR (> 50%-60% of patient cases), and histologic …