User profiles for Ajay Verma

Ajay Verma

Co-Founder and CEO, FVE Foundry
Verified email at formationve.com
Cited by 14169

Carbon monoxide: a putative neural messenger

A Verma, DJ Hirsch, CE Glatt, GV Ronnett, SH Snyder - Science, 1993 - science.org
Carbon monoxide, an activator of guanylyl cyclase, is formed by the action of the enzyme
heme oxygenase. By in situ hybridization in brain slices, discrete neuronal localization of …

[HTML][HTML] Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

H Lu, RA Forbes, A Verma - Journal of Biological Chemistry, 2002 - ASBMB
Cancer cells display high rates of aerobic glycolysis, a phenomenon known historically as
the Warburg effect. Lactate and pyruvate, the end products of glycolysis, are highly produced …

Poly (ADP-ribose) polymerase, nitric oxide and cell death

AA Pieper, A Verma, J Zhang, SH Snyder - Trends in pharmacological …, 1999 - cell.com
Poly (ADP-ribose) polymerase (PARP) is a nuclear enzyme that is activated by DNA strand
breaks to participate in DNA repair. Excessive activation of PARP, however, can deplete …

Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD

…, S Mehta, RCG Pollok, T Raine, PJ Smith, AM Verma… - Gut, 2021 - gut.bmj.com
Objective Delayed second dose SARS-CoV-2 vaccination trades maximal effectiveness for
a lower level of immunity across more of the population. We investigated whether patients …

Erythropoietin and erythropoietin receptor expression in human cancer

…, SM Beckwith, RL Pitts, E Clements, K Wong, A Verma - Cancer research, 2001 - AACR
Erythropoietin (EPO) stimulates the growth of erythroblasts in the bone marrow (C. Lacombe
and P. Mayeux, Nephrol. Dial. Transplant., 14 (Suppl. 2): 22–28, 1999). We report basal and …

[HTML][HTML] Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1

…, A Mohyeldin, T McFate, AS Tait, A Verma - Journal of Biological …, 2005 - ASBMB
Continuous hydroxylation of the HIF-1 transcription factor α subunit by oxygen and 2-oxoglutarate-dependent
dioxygenases promotes decay of this protein and thus prevents the …

Neuropathology provides clues to the pathophysiology of Gaucher disease

K Wong, E Sidransky, A Verma, T Mixon… - Molecular genetics and …, 2004 - Elsevier
To better understand the pathogenesis of brain dysfunction in Gaucher disease (GD), we
studied brain pathology in seven subjects with type 1 GD (four also exhibited parkinsonism and …

Variable latency speculative addition: A new paradigm for arithmetic circuit design

AK Verma, P Brisk, P Ienne - Proceedings of the conference on Design …, 2008 - dl.acm.org
Adders are one of the key components in arithmetic circuits. Enhancing their performance
can significantly improve the quality of arithmetic designs. This is the reason why the …

[HTML][HTML] Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

…, JA Califano, NH Jeoung, RA Harris, A Verma - Journal of Biological …, 2008 - ASBMB
High lactate generation and low glucose oxidation, despite normal oxygen conditions, are
commonly seen in cancer cells and tumors. Historically known as the Warburg effect, this …

Porphyrins are endogenous ligands for the mitochondrial (peripheral-type) benzodiazepine receptor.

A Verma, JS Nye, SH Snyder - Proceedings of the National …, 1987 - National Acad Sciences
"Peripheral-type" benzodiazepine receptors are localized to the outer mitochondrial membrane.
We have identified potent competitive inhibitors of these receptors and purified them …