[HTML][HTML] Zinc oxide nanoparticles induce necrosis and apoptosis in macrophages in a p47phox-and Nrf2-independent manner
…, B Stahlmecke, TAJ Kuhlbusch, AM Scherbart… - PloS one, 2013 - journals.plos.org
In view of the steadily increasing use of zinc oxide nanoparticles in various industrial and
consumer applications, toxicological investigations to evaluate their safety are highly justified. …
consumer applications, toxicological investigations to evaluate their safety are highly justified. …
[HTML][HTML] Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms
AM Scherbart, J Langer, A Bushmelev… - Particle and fibre …, 2011 - Springer
Inhalation of (nano)particles may lead to pulmonary inflammation. However, the precise
mechanisms of particle uptake and generation of inflammatory mediators by alveolar …
mechanisms of particle uptake and generation of inflammatory mediators by alveolar …
Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles
…, AW Boots, V Wilhelmi, AM Scherbart… - Free Radical Biology …, 2010 - Elsevier
The carcinogenicity of respirable quartz is considered to be driven by reactive oxygen species
(ROS) generation in association with chronic inflammation. The contribution of phagocyte-…
(ROS) generation in association with chronic inflammation. The contribution of phagocyte-…
Evaluation of cytotoxic effects and oxidative stress with hydroxyapatite dispersions of different physicochemical properties in rat NR8383 cells and primary …
C Albrecht, AM Scherbart, D van Berlo, CM Braunbarth… - Toxicology in vitro, 2009 - Elsevier
Enhanced cytotoxicity and oxidative stress through reactive oxygen species (ROS)
formation are discussed as relevant parameters regarding potential hazardous properties of …
formation are discussed as relevant parameters regarding potential hazardous properties of …
Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages
M Ghiazza, AM Scherbart, I Fenoglio… - Chemical research in …, 2011 - ACS Publications
The mechanism of enhancement/inhibition of quartz toxicity induced by iron is still unclear.
Here the amount of iron on a fibrogenic quartz (Qz) was increased by wet impregnation (Fe(…
Here the amount of iron on a fibrogenic quartz (Qz) was increased by wet impregnation (Fe(…
Investigation of the cytotoxic and proinflammatory effects of cement dusts in rat alveolar macrophages
…, K Gerloff, H Li, AM Scherbart… - Chemical research in …, 2009 - ACS Publications
Exposure to cement dust, a specifically alkaline and irritant dust, is one of the most common
occupational dust exposures worldwide. Although several adverse respiratory health effects …
occupational dust exposures worldwide. Although several adverse respiratory health effects …
Oxidative stress and DNA damage responses in rat and mouse lung to inhaled carbon nanoparticles
…, D Van Berlo, AW Boots, K Gerloff, AM Scherbart… - …, 2011 - Taylor & Francis
We have investigated whether short-term nose-only inhalation exposure to electric spark
discharge-generated carbon nanoparticles (∼60 nm) causes oxidative stress and DNA …
discharge-generated carbon nanoparticles (∼60 nm) causes oxidative stress and DNA …
[PDF][PDF] Mechanisms and Consequences of Particle Uptake in Alveolar Macrophages
AM Scherbart - Heinrich-Heine-Universitat Dusseldorf, 2010 - docserv.uni-duesseldorf.de
… To my parents Renata and Diethard Scherbart and To my sister Eva-Maria Scherbart … Most
experimental work presented, was done by Agnes M. Scherbart. The impact on authoring this …
experimental work presented, was done by Agnes M. Scherbart. The impact on authoring this …
Enhanced acute pulmonary inflammation and reduced fibrotic response in quartz-exposed p47phox-deficient mice
…, A Boots, A Wessels, V Wilhelmi, A Scherbart… - 2011 - Eur Respiratory Soc
Previous studies have shown that quartz (crystalline silica) provides a useful tool to study
experimental fibrosis in rodents. In the present study, we have investigated the involvement of …
experimental fibrosis in rodents. In the present study, we have investigated the involvement of …
[CITATION][C] Investigations of the contribution of neutrophils to the genotoxicity of respirable quartz particles
A Wessels, D van Berlo, V Wilhelmi, A Scherbart… - Toxicology Letters, 2009 - infona.pl
… Anton Wessels, Damien van Berlo, Verena Wilhelmi, Agnes Scherbart, Kirsten Gerloff,
Agnes Boots, Catrin Albrecht, Roel Schins …
Agnes Boots, Catrin Albrecht, Roel Schins …