[HTML][HTML] Zinc oxide nanoparticles induce necrosis and apoptosis in macrophages in a p47phox-and Nrf2-independent manner

…, B Stahlmecke, TAJ Kuhlbusch, AM Scherbart… - PloS one, 2013 - journals.plos.org
In view of the steadily increasing use of zinc oxide nanoparticles in various industrial and
consumer applications, toxicological investigations to evaluate their safety are highly justified. …

[HTML][HTML] Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms

AM Scherbart, J Langer, A Bushmelev… - Particle and fibre …, 2011 - Springer
Inhalation of (nano)particles may lead to pulmonary inflammation. However, the precise
mechanisms of particle uptake and generation of inflammatory mediators by alveolar …

Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles

…, AW Boots, V Wilhelmi, AM Scherbart… - Free Radical Biology …, 2010 - Elsevier
The carcinogenicity of respirable quartz is considered to be driven by reactive oxygen species
(ROS) generation in association with chronic inflammation. The contribution of phagocyte-…

Evaluation of cytotoxic effects and oxidative stress with hydroxyapatite dispersions of different physicochemical properties in rat NR8383 cells and primary …

C Albrecht, AM Scherbart, D van Berlo, CM Braunbarth… - Toxicology in vitro, 2009 - Elsevier
Enhanced cytotoxicity and oxidative stress through reactive oxygen species (ROS)
formation are discussed as relevant parameters regarding potential hazardous properties of …

Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages

M Ghiazza, AM Scherbart, I Fenoglio… - Chemical research in …, 2011 - ACS Publications
The mechanism of enhancement/inhibition of quartz toxicity induced by iron is still unclear.
Here the amount of iron on a fibrogenic quartz (Qz) was increased by wet impregnation (Fe(…

Investigation of the cytotoxic and proinflammatory effects of cement dusts in rat alveolar macrophages

…, K Gerloff, H Li, AM Scherbart… - Chemical research in …, 2009 - ACS Publications
Exposure to cement dust, a specifically alkaline and irritant dust, is one of the most common
occupational dust exposures worldwide. Although several adverse respiratory health effects …

Oxidative stress and DNA damage responses in rat and mouse lung to inhaled carbon nanoparticles

…, D Van Berlo, AW Boots, K Gerloff, AM Scherbart… - …, 2011 - Taylor & Francis
We have investigated whether short-term nose-only inhalation exposure to electric spark
discharge-generated carbon nanoparticles (∼60 nm) causes oxidative stress and DNA …

[PDF][PDF] Mechanisms and Consequences of Particle Uptake in Alveolar Macrophages

AM Scherbart - Heinrich-Heine-Universitat Dusseldorf, 2010 - docserv.uni-duesseldorf.de
… To my parents Renata and Diethard Scherbart and To my sister Eva-Maria Scherbart … Most
experimental work presented, was done by Agnes M. Scherbart. The impact on authoring this …

Enhanced acute pulmonary inflammation and reduced fibrotic response in quartz-exposed p47phox-deficient mice

…, A Boots, A Wessels, V Wilhelmi, A Scherbart… - 2011 - Eur Respiratory Soc
Previous studies have shown that quartz (crystalline silica) provides a useful tool to study
experimental fibrosis in rodents. In the present study, we have investigated the involvement of …

[CITATION][C] Investigations of the contribution of neutrophils to the genotoxicity of respirable quartz particles

A Wessels, D van Berlo, V Wilhelmi, A Scherbart… - Toxicology Letters, 2009 - infona.pl
… Anton Wessels, Damien van Berlo, Verena Wilhelmi, Agnes Scherbart, Kirsten Gerloff,
Agnes Boots, Catrin Albrecht, Roel Schins …