The human peripheral B-cell compartment displays a large population of immunoglobulin M–positive,
immunoglobulin D–positive CD27 + (IgM + IgD + CD27 + ) “memory” B cells …

The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive
clinical outcomes and responses to immunotherapy in cancer. Here, we used spatial …

The chicken immunoglobulin light chain repertoire has been shown to be entirely derived
from a single VhlJ rearranged combination. The complete coding information of the li locus …

Memory B cells are at the center of longstanding controversies regarding the presence of
antigen for their survival and their re-engagement in germinal centers after secondary …

The chicken heavy chain locus contains a single JH segment and a unique functional VH
gene (V” l) 15 kb upstream, wlth approximately 15 D elements in between. A cluster of …

Human marginal zone (MZ) B cells are, in a sense, a new entity. Although they share many
properties with their mouse counterpart, they also display striking differences, such as the …

Somatically mutated IgM + -only and IgM + IgD + CD27 + B lymphocytes comprise ≈25% of
the human peripheral B cell pool. These cells phenotypically resemble class-switched B …

Memory B cells play a fundamental role in host defenses against viruses, but to date, their
role has been relatively unsettled in the context of SARS-CoV-2. We report here a longitudinal …

Antibodies somatically mutate to attain high affinity in germinal centers (GCs). There, competition
between B cell clones and among somatic mutants of each clone drives an increase in …

Segmented filamentous bacterium (SFB) is a symbiont that drives postnatal maturation of gut
adaptive immune responses. In contrast to nonpathogenic E. coli, SFB stimulated vigorous …