Rationale: Asymmetric dimethylarginine (ADMA), a potent endogenous nitric oxide synthase
(NOS) inhibitor, is increased in idiopathic pulmonary arterial hypertension and associated …

Acute pulmonary embolism generally resolves within 6 months. However, if the thrombus is
infected, venous thrombi transform into fibrotic vascular obstructions leading to chronic deep …

Background Splenectomy is a clinical risk factor for complicated thrombosis. We hypothesized
that the loss of the mechanical filtering function of the spleen may enrich for thrombogenic …

Objectives : This study sought to define the prognostic significance and clinical determinants
of the 6-min walk distance (6-MWD) in affected patients. Background : Symptoms of …

Platelet endothelial cell adhesion molecule 1 (PECAM-1) is involved in leukocyte migration
and angiogenesis, which are key components of venous thrombus resolution. This study …

Aims Accumulation of extracellular matrix ( ECM ) is known to play a crucial role in the
pathophysiology of heart failure ( HF ). However, its prognostic relevance is poorly investigated. …

Alterations in the nitric oxide (NO) pathway play a major role in pulmonary arterial
hypertension (PAH). L-arginine (LA) and tetrahydrobiopterin (BH 4 ) are main substrates in the …

Purpose: Splenectomy is associated with complex venous thromboembolism such as recurrent
deep venous thrombosis, portal vein thrombosis, and chronic thromboembolic pulmonary …

Aneurysms of the ascending aorta rarely cause symptoms and are therefore often discovered
by chance. The definitive diagnosis requires a computed tomography scan or magnetic …

Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a late sequela
of venous thromboembolism affecting up to 4% patients surviving symptomatic pulmonary …