… Studies from Pang and Knox 42 have shown that bradykinin can also increase IL-8
release. Bradykinin, an important proinflammatory mediator in several inflammatory diseases, …

… These issues are discussed in this article by Simon Johnson and Alan Knox, who also
point to ways in which some of these pathways offer future therapeutic potential in asthma. …

… 46 Hamad AM, Range SP, Holland E, and Knox AJ. Desensitization of guanylyl cyclases in
cultured human airway smooth muscle cells. Am J Respir Cell Mol Biol 20: 1087-1095, 1999. …

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical
companies and six patient organisations with the objective of improving the understanding …

Background Inflammation and oxidative stress play critical roles in patients with chronic
obstructive pulmonary disease (COPD). Mitochondrial oxidative stress might be involved in …

We have investigated the relation between lung function and dietary intake of the antioxidant
vitamins C and E in the general population in a cross-sectional survey of a random sample …

Thirty six patients with chronic airflow obstruction were studied to examine (1) the reproducibility
and order effect of repeated walking tests when performed over consecutive days or …

In the FANTOM5 project, transcription initiation events across the human and mouse genomes
were mapped at a single base-pair resolution and their frequencies were monitored by …

Activation of latent transforming growth factor β (TGF-β) by αvβ6 integrin is critical in the
pathogenesis of lung injury and fibrosis. We have previously demonstrated that the stimulation of …

To investigate whether cessation of regular β-agonist treatment results in an increase in
bronchial responsiveness, two double-blind, randomised crossover studies were done. Subjects …