Promoting ecosystem and human health in urban areas using Green Infrastructure: A literature review

K Tzoulas, K Korpela, S Venn, V Yli-Pelkonen… - Landscape and urban …, 2007 - Elsevier
Europe is a highly urbanised continent. The consequent loss and degradation of urban and
peri-urban green space could adversely affect ecosystems as well as human health and well-…

Inhibition and induction of human cytochrome P450 enzymes: current status

O Pelkonen, M Turpeinen, J Hakkola, P Honkakoski… - Archives of …, 2008 - Springer
Variability of drug metabolism, especially that of the most important phase I enzymes or
cytochrome P450 (CYP) enzymes, is an important complicating factor in many areas of …

[HTML][HTML] Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

S Adler, D Basketter, S Creton, O Pelkonen… - Archives of …, 2011 - Springer
The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics
on the market in Europe after 2013. In that context, the European Commission invited …

[HTML][HTML] FinnGen provides genetic insights from a well-phenotyped isolated population

…, T Palotie, J Partanen, DS Paul, M Pelkonen… - Nature, 2023 - nature.com
Population isolates such as those in Finland benefit genetic research because deleterious
alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor …

FinnGen: Unique genetic insights from combining isolated population and national health register data

…, T Palotie, J Partanen, DS Paul, M Pelkonen… - MedRxiv, 2022 - medrxiv.org
Population isolates such as Finland provide benefits in genetic studies because the allelic
spectrum of damaging alleles in any gene is often concentrated on a small number of low-…

Using the ecosystem services approach for better planning and conservation of urban green spaces: a Finland case study

…, T Söderman, L Kopperoinen, V Yli-Pelkonen… - Biodiversity and …, 2010 - Springer
Ecosystem services are vital for humans in urban regions. However, urban development
poses a great risk for the ability of ecosystems to provide these services. In this paper we first …

Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis.

O Pelkonen, DW Nebert - Pharmacological reviews, 1982 - hero.epa.gov
One of the most useful theories to explain some mechanistic aspects of chemical carcinogenesis
is the theory of toxification, ie the formation of reactive metabolites by enzymes and the …

Child and adolescent suicide: epidemiology, risk factors, and approaches to prevention

M Pelkonen, M Marttunen - Pediatric Drugs, 2003 - Springer
Suicide is rare in childhood and early adolescence, and becomes more frequent with
increasing age. The latest mean worldwide annual rates of suicide per 100 000 were 0.5 for …

Depression and school performance in middle adolescent boys and girls

SA Fröjd, ES Nissinen, MUI Pelkonen… - Journal of …, 2008 - Elsevier
The study aimed to investigate the associations between different levels of depression with
different aspects of school performance. The target population included 2516 7th–9th grade …

Inhibition and induction of human cytochrome P450 (CYP) enzymes

O Pelkonen, J Mäeenpäeä, P Taavitsainen, A Rautio… - Xenobiotica, 1998 - Taylor & Francis
Detailed knowledge of metabolism of drugs is crucial for two main reasons. First, metabolism
determines to a large extent pharmacokinetic behaviour, interindividual variability and …