Severity assessment tools for predicting mortality in hospitalised patients with community-acquired pneumonia. Systematic review and meta-analysis
Introduction International guidelines recommend a severity-based approach to management
in community-acquired pneumonia. CURB65, CRB65 and the Pneumonia Severity Index (…
in community-acquired pneumonia. CURB65, CRB65 and the Pneumonia Severity Index (…
Severity assessment tools to guide ICU admission in community-acquired pneumonia: systematic review and meta-analysis
JD Chalmers, P Mandal, A Singanayagam… - Intensive care …, 2011 - Springer
Background The aim of this meta-analysis was to determine if severity assessment tools can
be used to guide decisions regarding intensive care unit (ICU) admission of patients with …
be used to guide decisions regarding intensive care unit (ICU) admission of patients with …
Lung microbiology and exacerbations in COPD
V Beasley, PV Joshi, A Singanayagam… - … journal of chronic …, 2012 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is the most common chronic respiratory
condition in adults and is characterized by progressive airflow limitation that is not fully reversible…
condition in adults and is characterized by progressive airflow limitation that is not fully reversible…
[PDF][PDF] Immunosuppression for hyperinflammation in COVID-19: a double-edged sword
AI Ritchie, A Singanayagam - Lancet, 2020 - udruzenjepedijatara.rs
Mehta and colleagues1 postulate that hyperinflammation in coronavirus disease 2019 (COVID-19)
could be a driver of severity that is amenable to therapeutic targeting since …
could be a driver of severity that is amenable to therapeutic targeting since …
[HTML][HTML] Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020
A Singanayagam, M Patel, A Charlett… - …, 2020 - eurosurveillance.org
Severe acute respiratory syndrome coronavirus 2 viral load in the upper respiratory tract
peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate …
peaks around symptom onset and infectious virus persists for 10 days in mild-to-moderate …
C-reactive protein is an independent predictor of severity in community-acquired pneumonia
BACKGROUND: C-reactive protein (CRP) is an acute phase protein synthesized by the liver
primarily in response to interleukin-6. Initial studies have suggested that inflammatory …
primarily in response to interleukin-6. Initial studies have suggested that inflammatory …
[HTML][HTML] Community transmission and viral load kinetics of the SARS-CoV-2 delta (B. 1.617. 2) variant in vaccinated and unvaccinated individuals in the UK: a …
A Singanayagam, S Hakki, J Dunning… - The lancet infectious …, 2022 - thelancet.com
Background The SARS-CoV-2 delta (B.1.617.2) variant is highly transmissible and spreading
globally, including in populations with high vaccination rates. We aimed to investigate …
globally, including in populations with high vaccination rates. We aimed to investigate …
Humoral and T-cell responses to SARS-CoV-2 vaccination in patients receiving immunosuppression
…, P Randell, A Shah, A Singanayagam… - Annals of the …, 2021 - ard.bmj.com
Objective There is an urgent need to assess the impact of immunosuppressive therapies on
the immunogenicity and efficacy of SARS-CoV-2 vaccination. Methods Serological and T-…
the immunogenicity and efficacy of SARS-CoV-2 vaccination. Methods Serological and T-…
Risk factors for complicated parapneumonic effusion and empyema on presentation to hospital with community-acquired pneumonia
JD Chalmers, A Singanayagam, MP Murray, C Scally… - Thorax, 2009 - thorax.bmj.com
Background: The aim of this study was to identify key factors on admission predicting the
development of complicated parapneumonic effusion or empyema in patients admitted with …
development of complicated parapneumonic effusion or empyema in patients admitted with …
Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK
C Bernsmeier, OT Pop, A Singanayagam… - Gastroenterology, 2015 - Elsevier
Background & Aims Characteristics of decompensated cirrhosis and acute-on-chronic liver
failure (ACLF) include susceptibility to infection, immuneparesis, and monocyte dysfunction. …
failure (ACLF) include susceptibility to infection, immuneparesis, and monocyte dysfunction. …