Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD).
However, only a minority of cigarette smokers develop symptomatic disease. Studies of …

In this paper we have summarized the evidence for a genetic contribution to asthma as well
as the recent advances in techniques for identifying the location and function of genes that …

Genetic factors including α 1 -antitrypsin deficiency are important in COPD. Candidate gene
association studies in COPD are reviewed. Efforts to identify interactions between genetic …

Background Polymorphisms in genes other than the cystic fibrosis transmembrane conductance
regulator (CFTR) gene may modify the severity of pulmonary disease in patients with …

Objectives: To determine the link between severity of COPD, oxidative stress, and NRF2-dependent
antioxidant levels in the peripheral lung tissue of patients with COPD. Methods: We …

Genome-wide association studies (GWAS) have identified loci reproducibly associated with
pulmonary diseases; however, the molecular mechanism underlying these associations are …

Atopy is a common familial state underlying allergic asthma and rhinitis. Lately, we have
assigned a gene for atopy to chromosome 11 q by linkage to the marker D11 S97. Since …

The matrix metalloproteinases (MMPs) comprise a family of at least 20 proteolytic enzymes
that play an essential role in tissue remodeling. MMP1 (interstitial collagenase), MMP9 (…

Atopy, a common familial syndrome underlying allergic asthma and rhinitis, is characterised
by sustained immunoglobulin E (IgE) responses to common allergens. We have previously …

A combined genome-wide association and linkage study was used to identify loci causing
variation in cystic fibrosis lung disease severity. We identified a significant association (P = …