[HTML][HTML] ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
A Hutloff, AM Dittrich, KC Beier, B Eljaschewitsch… - Nature, 1999 - nature.com
Originally published as Nature397, 263–266; 1999 The T-cell-specific cell-surface receptors
CD28 and CTLA-4 are important regulators of the immune system. CD28 potently enhances …
CD28 and CTLA-4 are important regulators of the immune system. CD28 potently enhances …
Induction, binding specificity and function of human ICOS
KC Beier, A Hutloff, AM Dittrich, C Heuck… - European journal of …, 2000 - Wiley Online Library
Recently, we have identified the inducible co‐stimulator (ICOS), an activation‐dependent, T
cell‐specific cell surface molecule related to CD28 and CTLA‐4. Detailed analysis of human …
cell‐specific cell surface molecule related to CD28 and CTLA‐4. Detailed analysis of human …
Effects of Elexacaftor/Tezacaftor/Ivacaftor Therapy on CFTR Function in Patients with Cystic Fibrosis and One or Two F508del Alleles
…, S Hirtz, O Sommerburg, AM Dittrich… - American journal of …, 2022 - atsjournals.org
Rationale: The CFTR (cystic fibrosis transmembrane conductance regulator) modulator
combination elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was shown to improve clinical …
combination elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was shown to improve clinical …
Effects of elexacaftor/tezacaftor/ivacaftor therapy on lung clearance index and magnetic resonance imaging in patients with cystic fibrosis and one or two F508del …
Rationale: We recently demonstrated that triple-combination CFTR (cystic fibrosis transmembrane
conductance regulator) modulator therapy with elexacaftor/tezacaftor/ivacaftor (ELX/…
conductance regulator) modulator therapy with elexacaftor/tezacaftor/ivacaftor (ELX/…
Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine …
AM Dittrich, A Erbacher, S Specht, F Diesner… - The journal of …, 2008 - journals.aai.org
Numerous epidemiological studies have shown an inverse correlation between helminth
infections and the manifestation of atopic diseases, yet the immunological mechanisms …
infections and the manifestation of atopic diseases, yet the immunological mechanisms …
Preventive inhalation of hypertonic saline in infants with cystic fibrosis (PRESIS). A randomized, double-blind, controlled study
…, L Nährlich, AM Dittrich… - American journal of …, 2019 - atsjournals.org
Rationale: Cystic fibrosis (CF) lung disease starts in early infancy, suggesting that preventive
treatment may be most beneficial. Lung clearance index (LCI) and chest magnetic …
treatment may be most beneficial. Lung clearance index (LCI) and chest magnetic …
Gene correction of human induced pluripotent stem cells repairs the cellular phenotype in pulmonary alveolar proteinosis
…, A Mucci, J Skuljec, AM Dittrich… - American journal of …, 2014 - atsjournals.org
Rationale: Hereditary pulmonary alveolar proteinosis (hPAP) caused by granulocyte–macrophage
colony–stimulating factor (GM-CSF) receptor α-chain (CSF2RA) deficiency is a rare, …
colony–stimulating factor (GM-CSF) receptor α-chain (CSF2RA) deficiency is a rare, …
[HTML][HTML] Expression and function of histamine and its receptors in atopic dermatitis
M Albrecht, AM Dittrich - Molecular and cellular pediatrics, 2015 - Springer
Background Atopic dermatitis constitutes a most burdensome chronic inflammatory skin
disease. Standard treatment is cumbersome and often targets its main symptom, pruritus, only …
disease. Standard treatment is cumbersome and often targets its main symptom, pruritus, only …
[HTML][HTML] T2-high asthma phenotypes across lifespan
…, S Illi, D Thiele, C Skevaki, AM Dittrich… - European …, 2022 - Eur Respiratory Soc
Rationale In adults, personalised asthma treatment targets patients with type 2 (T2)-high and
eosinophilic asthma phenotypes. It is unclear whether such classification is achievable in …
eosinophilic asthma phenotypes. It is unclear whether such classification is achievable in …
[HTML][HTML] The all age asthma cohort (ALLIANCE)-from early beginnings to chronic disease: a longitudinal cohort study
O Fuchs, T Bahmer, M Weckmann, AM Dittrich… - BMC pulmonary …, 2018 - Springer
Background Asthma and wheezing disorders in childhood and adulthood are clinically
heterogeneous regarding disease presentation, natural course, and response to treatment. …
heterogeneous regarding disease presentation, natural course, and response to treatment. …