The northern Grant Range, in east-central Nevada, is a north-trending range bounded on
the west by a west-dipping normal fault. The northwestern flank of the Grant Range exposes …

The United States Environmental Protection Agency issues periodic reports that describe air
quality trends in the US. For some pollutants, such as ozone, both observed and …

A series of novel curcumin analogs were synthesized and screened for anti-cancer and anti-angiogenesis
activities at Emory University and at the National Cancer Institute (NCI). These …

Advancement of potential anti-cancer agents from “discovery” in an in vitro screen to pre-clinical
development requires a demonstration of in vivo efficacy in one or more animal models …

To date, over 100 small-molecule oncology drugs have been approved by the FDA. Because
of the inherent heterogeneity of tumors, these small molecules are often administered in …

Background Many antitumor drugs require metabolic activation to exert their cytotoxic or
cytostatic effects. The socalled bioreductive compounds, whose conversion into active antitumor …

Programmed cell death 4 (Pdcd4) is a novel repressor of in vitro transformation. Pdcd4 directly
inhibits the helicase activity of eukaryotic translation initiation factor 4A, a component of …

Many key processes central to bone formation and homeostasis require the involvement of
osteoblasts, cells responsible for accumulation and mineralization of the extracellular matrix (…

The “cosmopolitanization of reality” is, contrary to conspiracy theories of various sorts, an
unforeseen social consequence of actions directed at other results in a context of global …

Programmed cell death 4 (Pdcd4), originally identified as an inhibitor of murine cellular
transformation, inhibits protein synthesis by directly interacting with eukaryotic initiation factor 4A (…