Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis
X Li, M Molina-Molina, A Abdul-Hafez… - … of Physiology-Lung …, 2008 - journals.physiology.org
Earlier work from this laboratory showed that local generation of angiotensin (ANG) II is
required for the pathogenesis of experimental pulmonary fibrosis and that ANG peptides are …
required for the pathogenesis of experimental pulmonary fibrosis and that ANG peptides are …
Regulation of alveolar epithelial cell survival by the ACE-2/angiotensin 1–7/Mas axis
…, X Li, A Xue, X Gao, A Abdul-Hafez - American Journal of …, 2011 - journals.physiology.org
Earlier work from this laboratory demonstrated that apoptosis of alveolar epithelial cells (AECs)
requires autocrine generation of angiotensin (ANG) II. More recent studies showed that …
requires autocrine generation of angiotensin (ANG) II. More recent studies showed that …
[HTML][HTML] Stem-cell therapy for bronchopulmonary dysplasia (BPD) in newborns
Premature newborns are at a higher risk for the development of respiratory distress syndrome
(RDS), acute lung injury (ALI) associated with lung inflammation, disruption of alveolar …
(RDS), acute lung injury (ALI) associated with lung inflammation, disruption of alveolar …
Extravascular sources of lung angiotensin peptide synthesis in idiopathic pulmonary fibrosis
X Li, M Molina-Molina, A Abdul-Hafez… - … of Physiology-Lung …, 2006 - journals.physiology.org
Previous work from this laboratory demonstrated de novo synthesis of angiotensin (ANG)
peptides by apoptotic pulmonary alveolar epithelial cells (AEC) and by lung myofibroblasts in …
peptides by apoptotic pulmonary alveolar epithelial cells (AEC) and by lung myofibroblasts in …
Cell cycle dependence of ACE-2 explains downregulation in idiopathic pulmonary fibrosis
…, R Llatos, E Cano, A Abdul-Hafez… - European …, 2013 - Eur Respiratory Soc
Alveolar epithelial type II cells, a major source of angiotensin-converting enzyme (ACE)-2 in
the adult lung, are normally quiescent but actively proliferate in lung fibrosis and …
the adult lung, are normally quiescent but actively proliferate in lung fibrosis and …
[HTML][HTML] The renin angiotensin system in liver and lung: impact and therapeutic potential in organ fibrosis
A Abdul-Hafez, T Mohamed, H Omar… - Journal of lung …, 2018 - ncbi.nlm.nih.gov
Liver and lung fibrosis are two main organ diseases that are of particular importance in both
Egypt and the US. Hepatitis C Virus “HCV” infection and idiopathic pulmonary fibrosis (IPF) …
Egypt and the US. Hepatitis C Virus “HCV” infection and idiopathic pulmonary fibrosis (IPF) …
[HTML][HTML] JunD and HIF-1α mediate transcriptional activation of angiotensinogen by TGF-β1 in human lung fibroblasts
A Abdul-Hafez, R Shu, BD Uhal - The FASEB Journal, 2009 - ncbi.nlm.nih.gov
Earlier work showed that TGF-β1 potently increases angiotensinogen (AGT) gene mRNA in
primary human lung fibroblasts. Here the mechanism of TGF-β1-induced AGT expression …
primary human lung fibroblasts. Here the mechanism of TGF-β1-induced AGT expression …
[HTML][HTML] Oxygen injury in neonates: which is worse? hyperoxia, hypoxia, or alternating hyperoxia/hypoxia
T Mohamed, A Abdul-Hafez, IH Gewolb… - Journal of lung …, 2020 - ncbi.nlm.nih.gov
Premature birth results in an increased risk of respiratory distress and often requires oxygen
therapy. While the supplemental oxygen has been implicated as a cause of …
therapy. While the supplemental oxygen has been implicated as a cause of …
Angiotensinogen gene G-6A polymorphism influences idiopathic pulmonary fibrosis disease progression
…, A Xaubet, X Li, A Abdul-Hafez… - European …, 2008 - Eur Respiratory Soc
Angiotensin II is a growth factor that plays a key role in the physiopathology of idiopathic
pulmonary fibrosis (IPF). A nucleotide substitution of an adenine instead of a guanine (G-6A) in …
pulmonary fibrosis (IPF). A nucleotide substitution of an adenine instead of a guanine (G-6A) in …
Prior hypoxia prevents downregulation of ACE-2 by hyperoxia in fetal human lung fibroblasts
TL Mohamed, HT Nguyen, A Abdul-Hafez… - Experimental lung …, 2016 - Taylor & Francis
Purpose/Aim of Study: The renin angiotensin system is involved in experimentally induced
lung fibrosis. Angiotensin (ANG)-II is profibrotic. Angiotensin converting enzyme-2 (ACE-2) …
lung fibrosis. Angiotensin (ANG)-II is profibrotic. Angiotensin converting enzyme-2 (ACE-2) …