Deleterious impact of Pseudomonas aeruginosa on cystic fibrosis transmembrane conductance regulator function and rescue in airway epithelial cells
NTN Trinh, C Bilodeau, É Maillé… - European …, 2015 - Eur Respiratory Soc
The epithelial response to bacterial airway infection, a common feature of lung diseases such
as chronic obstructive pulmonary disease and cystic fibrosis, has been extensively studied…
as chronic obstructive pulmonary disease and cystic fibrosis, has been extensively studied…
Vx-809/Vx-770 treatment reduces inflammatory response to Pseudomonas aeruginosa in primary differentiated cystic fibrosis bronchial epithelial cells
M Ruffin, L Roussel, É Maillé… - … of Physiology-Lung …, 2018 - journals.physiology.org
Cystic fibrosis patients exhibit chronic Pseudomonas aeruginosa respiratory infections and
sustained proinflammatory state favoring lung tissue damage and remodeling, ultimately …
sustained proinflammatory state favoring lung tissue damage and remodeling, ultimately …
Staphylococcus aureus impairs sinonasal epithelial repair: effects in patients with chronic rhinosinusitis with nasal polyps and control subjects
FCP Valera, M Ruffin, D Adam, É Maillé… - Journal of Allergy and …, 2019 - Elsevier
… Author links open overlay panel Fabiana CP Valera MD, PhD a b ∗ , Manon Ruffin PhD a c
∗ , Damien Adam PhD a c , Émilie Maillé MSc a , Badr Ibrahim MD a d , Julie Berube MSc e , …
∗ , Damien Adam PhD a c , Émilie Maillé MSc a , Badr Ibrahim MD a d , Julie Berube MSc e , …
[HTML][HTML] CFTR rescue with VX-809 and VX-770 favors the repair of primary airway epithelial cell cultures from patients with class II mutations in the presence of …
D Adam, C Bilodeau, L Sognigbé, É Maillé… - Journal of Cystic …, 2018 - Elsevier
Background Progressive airway damage due to bacterial infections, especially with
Pseudomonas aeruginosa remains the first cause of morbidity and mortality in CF patients. Our …
Pseudomonas aeruginosa remains the first cause of morbidity and mortality in CF patients. Our …
[HTML][HTML] Quorum-sensing inhibition abrogates the deleterious impact of Pseudomonas aeruginosa on airway epithelial repair
M Ruffin, C Bilodeau, E Maillé, SL LaFayette… - The FASEB …, 2016 - ncbi.nlm.nih.gov
Chronic Pseudomonas aeruginosa lung infections are associated with progressive epithelial
damage and lung function decline. In addition to its role in tissue injury, the persistent …
damage and lung function decline. In addition to its role in tissue injury, the persistent …
EGF and K+ channel activity control normal and cystic fibrosis bronchial epithelia repair
NTN Trinh, A Privé, E Maillé, J Noël… - American Journal of …, 2008 - journals.physiology.org
Severe lesions of airway epithelia are observed in cystic fibrosis (CF) patients. The regulatory
mechanisms of cell migration and proliferation processes, involved in the repair of injured …
mechanisms of cell migration and proliferation processes, involved in the repair of injured …
Improvement of defective cystic fibrosis airway epithelial wound repair after CFTR rescue
NTN Trinh, O Bardou, A Privé, E Maillé… - European …, 2012 - Eur Respiratory Soc
Airway damage and remodelling are important components of lung pathology progression
in cystic fibrosis (CF). Although repair mechanisms are engaged to restore the epithelial …
in cystic fibrosis (CF). Although repair mechanisms are engaged to restore the epithelial …
[HTML][HTML] Quorum Sensing Down-Regulation Counteracts the Negative Impact of Pseudomonas aeruginosa on CFTR Channel Expression, Function and Rescue in …
É Maillé, M Ruffin, D Adam, H Messaoud… - Frontiers in cellular …, 2017 - frontiersin.org
The function of cystic fibrosis transmembrane conductance regulator (CFTR) channels is
crucial in human airways. However unfortunately, chronic Pseudomonas aeruginosa infection …
crucial in human airways. However unfortunately, chronic Pseudomonas aeruginosa infection …
[HTML][HTML] Deleterious impact of hyperglycemia on cystic fibrosis airway ion transport and epithelial repair
C Bilodeau, O Bardou, É Maillé, Y Berthiaume… - Journal of Cystic …, 2016 - Elsevier
Background Cystic fibrosis (CF)-related diabetes (CFRD) is associated with faster pulmonary
function decline. Thus, we evaluated the impact of hyperglycemia on airway epithelial …
function decline. Thus, we evaluated the impact of hyperglycemia on airway epithelial …
[HTML][HTML] Impact of KvLQT1 potassium channel modulation on alveolar fluid homeostasis in an animal model of thiourea-induced lung edema
…, A Girault, D Adam, J Chebli, É Maillé… - Frontiers in …, 2023 - frontiersin.org
Alveolar ion and fluid absorption is essential for lung homeostasis in healthy conditions as
well as for the resorption of lung edema, a key feature of acute respiratory distress syndrome. …
well as for the resorption of lung edema, a key feature of acute respiratory distress syndrome. …