Deleterious impact of Pseudomonas aeruginosa on cystic fibrosis transmembrane conductance regulator function and rescue in airway epithelial cells

NTN Trinh, C Bilodeau, É Maillé… - European …, 2015 - Eur Respiratory Soc
The epithelial response to bacterial airway infection, a common feature of lung diseases such
as chronic obstructive pulmonary disease and cystic fibrosis, has been extensively studied…

Vx-809/Vx-770 treatment reduces inflammatory response to Pseudomonas aeruginosa in primary differentiated cystic fibrosis bronchial epithelial cells

M Ruffin, L Roussel, É Maillé… - … of Physiology-Lung …, 2018 - journals.physiology.org
Cystic fibrosis patients exhibit chronic Pseudomonas aeruginosa respiratory infections and
sustained proinflammatory state favoring lung tissue damage and remodeling, ultimately …

Staphylococcus aureus impairs sinonasal epithelial repair: effects in patients with chronic rhinosinusitis with nasal polyps and control subjects

FCP Valera, M Ruffin, D Adam, É Maillé… - Journal of Allergy and …, 2019 - Elsevier
… Author links open overlay panel Fabiana CP Valera MD, PhD a b ∗ , Manon Ruffin PhD a c
∗ , Damien Adam PhD a c , Émilie Maillé MSc a , Badr Ibrahim MD a d , Julie Berube MSc e , …

[HTML][HTML] CFTR rescue with VX-809 and VX-770 favors the repair of primary airway epithelial cell cultures from patients with class II mutations in the presence of …

D Adam, C Bilodeau, L Sognigbé, É Maillé… - Journal of Cystic …, 2018 - Elsevier
Background Progressive airway damage due to bacterial infections, especially with
Pseudomonas aeruginosa remains the first cause of morbidity and mortality in CF patients. Our …

[HTML][HTML] Quorum-sensing inhibition abrogates the deleterious impact of Pseudomonas aeruginosa on airway epithelial repair

M Ruffin, C Bilodeau, E Maillé, SL LaFayette… - The FASEB …, 2016 - ncbi.nlm.nih.gov
Chronic Pseudomonas aeruginosa lung infections are associated with progressive epithelial
damage and lung function decline. In addition to its role in tissue injury, the persistent …

EGF and K+ channel activity control normal and cystic fibrosis bronchial epithelia repair

NTN Trinh, A Privé, E Maillé, J Noël… - American Journal of …, 2008 - journals.physiology.org
Severe lesions of airway epithelia are observed in cystic fibrosis (CF) patients. The regulatory
mechanisms of cell migration and proliferation processes, involved in the repair of injured …

Improvement of defective cystic fibrosis airway epithelial wound repair after CFTR rescue

NTN Trinh, O Bardou, A Privé, E Maillé… - European …, 2012 - Eur Respiratory Soc
Airway damage and remodelling are important components of lung pathology progression
in cystic fibrosis (CF). Although repair mechanisms are engaged to restore the epithelial …

[HTML][HTML] Quorum Sensing Down-Regulation Counteracts the Negative Impact of Pseudomonas aeruginosa on CFTR Channel Expression, Function and Rescue in …

É Maillé, M Ruffin, D Adam, H Messaoud… - Frontiers in cellular …, 2017 - frontiersin.org
The function of cystic fibrosis transmembrane conductance regulator (CFTR) channels is
crucial in human airways. However unfortunately, chronic Pseudomonas aeruginosa infection …

[HTML][HTML] Deleterious impact of hyperglycemia on cystic fibrosis airway ion transport and epithelial repair

C Bilodeau, O Bardou, É Maillé, Y Berthiaume… - Journal of Cystic …, 2016 - Elsevier
Background Cystic fibrosis (CF)-related diabetes (CFRD) is associated with faster pulmonary
function decline. Thus, we evaluated the impact of hyperglycemia on airway epithelial …

[HTML][HTML] Impact of KvLQT1 potassium channel modulation on alveolar fluid homeostasis in an animal model of thiourea-induced lung edema

…, A Girault, D Adam, J Chebli, É Maillé… - Frontiers in …, 2023 - frontiersin.org
Alveolar ion and fluid absorption is essential for lung homeostasis in healthy conditions as
well as for the resorption of lung edema, a key feature of acute respiratory distress syndrome. …