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Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α-dependent pathways.
Morianos I, Trochoutsou AI, Papadopoulou G, Semitekolou M, Banos A, Konstantopoulos D, Manousopoulou A, Kapasa M, Wei P, Lomenick B, Belaidi E, Kalamatas T, Karageorgiou K, Doskas T, Sallusto F, Pan F, Garbis SD, Quintana FJ, Xanthou G. Morianos I, et al. Among authors: trochoutsou ai. Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12269-12280. doi: 10.1073/pnas.1918196117. Epub 2020 May 14. Proc Natl Acad Sci U S A. 2020. PMID: 32409602 Free PMC article.
Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses.
Tousa S, Semitekolou M, Morianos I, Banos A, Trochoutsou AI, Brodie TM, Poulos N, Samitas K, Kapasa M, Konstantopoulos D, Paraskevopoulos G, Gaga M, Hawrylowicz CM, Sallusto F, Xanthou G. Tousa S, et al. Among authors: trochoutsou ai. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2891-E2900. doi: 10.1073/pnas.1616942114. Epub 2017 Mar 20. Proc Natl Acad Sci U S A. 2017. PMID: 28320933 Free PMC article.
Tolerogenic signaling by pulmonary CD1c+ dendritic cells induces regulatory T cells in patients with chronic obstructive pulmonary disease by IL-27/IL-10/inducible costimulator ligand.
Tsoumakidou M, Tousa S, Semitekolou M, Panagiotou P, Panagiotou A, Morianos I, Litsiou E, Trochoutsou AI, Konstantinou M, Potaris K, Footitt J, Mallia P, Zakynthinos S, Johnston SL, Xanthou G. Tsoumakidou M, et al. Among authors: trochoutsou ai. J Allergy Clin Immunol. 2014 Oct;134(4):944-954.e8. doi: 10.1016/j.jaci.2014.05.045. Epub 2014 Jul 19. J Allergy Clin Immunol. 2014. PMID: 25051954