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Isolated Schistosoma mansoni eggs prevent allergic airway inflammation.
Obieglo K, Schuijs MJ, Ozir-Fazalalikhan A, Otto F, van Wijck Y, Boon L, Lambrecht BN, Taube C, Smits HH. Obieglo K, et al. Parasite Immunol. 2018 Oct;40(10):e12579. doi: 10.1111/pim.12579. Epub 2018 Sep 16. Parasite Immunol. 2018. PMID: 30107039 Free PMC article.
Production and glyco-engineering of immunomodulatory helminth glycoproteins in plants.
Wilbers RH, Westerhof LB, van Noort K, Obieglo K, Driessen NN, Everts B, Gringhuis SI, Schramm G, Goverse A, Smant G, Bakker J, Smits HH, Yazdanbakhsh M, Schots A, Hokke CH. Wilbers RH, et al. Among authors: obieglo k. Sci Rep. 2017 Apr 10;7:45910. doi: 10.1038/srep45910. Sci Rep. 2017. PMID: 28393916 Free PMC article.
Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells.
Haeberlein S, Obieglo K, Ozir-Fazalalikhan A, Chayé MAM, Veninga H, van der Vlugt LEPM, Voskamp A, Boon L, den Haan JMM, Westerhof LB, Wilbers RHP, Schots A, Schramm G, Hokke CH, Smits HH. Haeberlein S, et al. Among authors: obieglo k. PLoS Pathog. 2017 Jul 28;13(7):e1006539. doi: 10.1371/journal.ppat.1006539. eCollection 2017 Jul. PLoS Pathog. 2017. PMID: 28753651 Free PMC article.