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Concentration-QT Modeling Following Inhalation of the Novel Inhaled Phosphodiesterase-4 Inhibitor CHF6001 in Healthy Volunteers Shows an Absence of QT Prolongation.
Jolling K, Äbelö A, Luyckx N, Nandeuil MA, Govoni M, Cella M, Lindauer A. Jolling K, et al. Among authors: nandeuil ma. CPT Pharmacometrics Syst Pharmacol. 2019 Jul;8(7):460-468. doi: 10.1002/psp4.12405. Epub 2019 May 11. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31077576 Free PMC article.
Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis.
Govoni M, Bassi M, Vezzoli S, Lucci G, Emirova A, Nandeuil MA, Petruzzelli S, Jellema GL, Afolabi EK, Colgan B, Leaker B, Kornmann O, Beeh KM, Watz H, Singh D. Govoni M, et al. Among authors: nandeuil ma. Respir Res. 2020 Mar 20;21(1):72. doi: 10.1186/s12931-020-1329-y. Respir Res. 2020. PMID: 32197620 Free PMC article. Clinical Trial.
Safety, tolerability, and pharmacokinetics of single and repeat ascending doses of CHF6001, a novel inhaled phosphodiesterase-4 inhibitor: two randomized trials in healthy volunteers.
Mariotti F, Govoni M, Lucci G, Santoro D, Nandeuil MA. Mariotti F, et al. Among authors: nandeuil ma. Int J Chron Obstruct Pulmon Dis. 2018 Oct 18;13:3399-3410. doi: 10.2147/COPD.S174156. eCollection 2018. Int J Chron Obstruct Pulmon Dis. 2018. PMID: 30425469 Free PMC article. Clinical Trial.