This paper focuses on the technical solutions enabling the monitoring of health conditions by means of ECG, HR, oxygen saturation, impedance pneumography and activity patterns. The Healthwear service is based on the Wealthy prototype system. A new design has been made to increase comfort in wearing of the system during daily patient activities. The cloth is connected to a patient portable electronic unit (PPU) that acquires and elaborates the signals from the sensors. The PPU transmits the signal to a central processing site through the use of GPRS wireless technology. This service is applied to three distinct clinical contexts: rehabilitation of cardiac patients, following an acute event; early discharge program in chronic respiration patients; promotion of physical activity in ambulatory stable cardio-respiratory patients.