[Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan]

Mol Biol (Mosk). 2014 Mar-Apr;48(2):265-76.
[Article in Russian]

Abstract

Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disease developing as a result of the interaction between genetic predisposition and environmental factors. Considerable role in allergic diseases development is played by polymorphisms of genes of pattern-recognition receptors (PRR) which are capable of recognizing conservative standard molecular structures (patterns) unique for large pathogen groups. In this study polymorphic variants of PRR genes--Toll-like receptors (TLR1, TLR2, TLR4, TLR5, TLR6, TLR9, TLR10), NOD-like receptors (NOD1, NOD2), lipopolysaccharide receptor CD14 gene, and C11orf30 and LRRC32 genes, located in 11q13.5 region, have been investigated in AD patients and control subjects from the Republic of Bashkortostan. An association of TLR1 (rs5743571 and rs5743604), TLR6 (rs5743794) and TLR10 (rs11466617) with AD was found. Our results confirm an important role of the innate immune system in the pathogenesis of AD and the significance of polymorphisms within the Toll-like receptor 2 subfamily genes in AD development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Alleles
  • Bashkiria
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Chromosomes, Human, Pair 11
  • Dermatitis, Atopic / genetics*
  • Dermatitis, Atopic / immunology
  • Dermatitis, Atopic / pathology
  • Female
  • Gene Expression
  • Gene Frequency
  • Gene-Environment Interaction
  • Genetic Loci
  • Genetic Predisposition to Disease*
  • Humans
  • Lipopolysaccharide Receptors / genetics
  • Lipopolysaccharide Receptors / immunology
  • Male
  • Membrane Proteins / genetics
  • Membrane Proteins / immunology
  • Middle Aged
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / immunology
  • Nod1 Signaling Adaptor Protein / genetics
  • Nod1 Signaling Adaptor Protein / immunology
  • Nod2 Signaling Adaptor Protein / genetics
  • Nod2 Signaling Adaptor Protein / immunology
  • Nuclear Proteins / genetics
  • Nuclear Proteins / immunology
  • Polymorphism, Genetic*
  • Repressor Proteins / genetics
  • Repressor Proteins / immunology
  • Toll-Like Receptors / genetics*
  • Toll-Like Receptors / immunology

Substances

  • EMSY protein, human
  • LRRC32 protein, human
  • Lipopolysaccharide Receptors
  • Membrane Proteins
  • NOD1 protein, human
  • NOD2 protein, human
  • Neoplasm Proteins
  • Nod1 Signaling Adaptor Protein
  • Nod2 Signaling Adaptor Protein
  • Nuclear Proteins
  • Repressor Proteins
  • Toll-Like Receptors