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Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain.
Simpson K, Leyendecker P, Hopp M, Müller-Lissner S, Löwenstein O, De Andrés J, Troy Ferrarons J, Bosse B, Krain B, Nichols T, Kremers W, Reimer K. Simpson K, et al. Among authors: krain b. Curr Med Res Opin. 2008 Dec;24(12):3503-12. doi: 10.1185/03007990802584454. Curr Med Res Opin. 2008. PMID: 19032132 Clinical Trial.
Combined prolonged-release oxycodone and naloxone improves bowel function in patients receiving opioids for moderate-to-severe non-malignant chronic pain: a randomised controlled trial.
Löwenstein O, Leyendecker P, Hopp M, Schutter U, Rogers PD, Uhl R, Bond S, Kremers W, Nichols T, Krain B, Reimer K. Löwenstein O, et al. Among authors: krain b. Expert Opin Pharmacother. 2009 Mar;10(4):531-43. doi: 10.1517/14656560902796798. Expert Opin Pharmacother. 2009. PMID: 19243306 Clinical Trial.