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Page 1
Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme.
Krug N, Hohlfeld JM, Kirsten AM, Kornmann O, Beeh KM, Kappeler D, Korn S, Ignatenko S, Timmer W, Rogon C, Zeitvogel J, Zhang N, Bille J, Homburg U, Turowska A, Bachert C, Werfel T, Buhl R, Renz J, Garn H, Renz H. Krug N, et al. Among authors: kappeler d. N Engl J Med. 2015 May 21;372(21):1987-95. doi: 10.1056/NEJMoa1411776. Epub 2015 May 17. N Engl J Med. 2015. PMID: 25981191 Free article. Clinical Trial.
Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis.
Barth P, Bruijnzeel P, Wach A, Sellier Kessler O, Hooftman L, Zimmermann J, Naue N, Huber B, Heimbeck I, Kappeler D, Timmer W, Chevalier E. Barth P, et al. Among authors: kappeler d. J Cyst Fibros. 2020 Mar;19(2):299-304. doi: 10.1016/j.jcf.2019.08.020. Epub 2019 Sep 6. J Cyst Fibros. 2020. PMID: 31501052 Free article. Clinical Trial.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel CRTH2 Antagonist BI 1021958 at Single Oral Doses in Healthy Men and Multiple Oral Doses in Men and Women With Well-Controlled Asthma.
Fowler A, Koenen R, Hilbert J, Blatchford J, Kappeler D, Benediktus E, Wood C, Gupta A. Fowler A, et al. Among authors: kappeler d. J Clin Pharmacol. 2017 Nov;57(11):1444-1453. doi: 10.1002/jcph.947. Epub 2017 Jun 13. J Clin Pharmacol. 2017. PMID: 28609567 Clinical Trial.
Lung Deposition of Alpha1-Proteinase Inhibitor (Human) (A1-PI[H]) Inhalation Solution Using Two Inhalation Modes of the I-neb Adaptive Aerosol Delivery (AAD) System in Healthy Subjects and Subjects with Cystic Fibrosis.
Häussermann S, Winnips C, Edelman J, Kappeler D, Herpich C, Ehlich H, Zanker D, Kietzig C, Sommerer K. Häussermann S, et al. Among authors: kappeler d. J Aerosol Med Pulm Drug Deliv. 2016 Jun;29(3):242-50. doi: 10.1089/jamp.2014.1173. Epub 2015 Dec 15. J Aerosol Med Pulm Drug Deliv. 2016. PMID: 26669827 Clinical Trial.