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A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts.
Grosch M, Brunner K, Ilyaskin AV, Schober M, Staudner T, Schmied D, Stumpp T, Schmidt KN, Madej MG, Pessoa TD, Othmen H, Kubitza M, Osten L, de Vries U, Mair MM, Somlo S, Moser M, Kunzelmann K, Ziegler C, Haerteis S, Korbmacher C, Witzgall R. Grosch M, et al. Among authors: ilyaskin av. J Cell Sci. 2021 Aug 15;134(16):jcs259013. doi: 10.1242/jcs.259013. Epub 2021 Aug 23. J Cell Sci. 2021. PMID: 34345895 Free PMC article.
Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice.
Essigke D, Ilyaskin AV, Wörn M, Bohnert BN, Xiao M, Daniel C, Amann K, Birkenfeld AL, Szabo R, Bugge TH, Korbmacher C, Artunc F. Essigke D, et al. Among authors: ilyaskin av. Acta Physiol (Oxf). 2021 May;232(1):e13640. doi: 10.1111/apha.13640. Epub 2021 Mar 11. Acta Physiol (Oxf). 2021. PMID: 33650216 Free PMC article.
Proteolytic activation of the epithelial sodium channel (ENaC) by factor VII activating protease (FSAP) and its relevance for sodium retention in nephrotic mice.
Artunc F, Bohnert BN, Schneider JC, Staudner T, Sure F, Ilyaskin AV, Wörn M, Essigke D, Janessa A, Nielsen NV, Birkenfeld AL, Etscheid M, Haerteis S, Korbmacher C, Kanse SM. Artunc F, et al. Among authors: ilyaskin av. Pflugers Arch. 2022 Feb;474(2):217-229. doi: 10.1007/s00424-021-02639-7. Epub 2021 Dec 6. Pflugers Arch. 2022. PMID: 34870751 Free PMC article.
19 results