[Sudden death in organophosphoric poisoning--an unaccountable pathophysiologic mechanism?]

Rev Med Chir Soc Med Nat Iasi. 2004 Apr-Jun;108(2):325-8.
[Article in Romanian]

Abstract

Sudden death related in literature to appear in IV-th - VIII-th day from organophosphoric intoxication does not have an unanimous accepted physiopathologic explanation.

Purpose: Pharmacodynamic study of myocardial trichlorfon level in acute experiment.

Material and method: Gas chromatographic determination of myocardial trichlorfon quantity in an experiment on white, male Wistar rats, daily sacrificed for the heart, until the tenth day from an digestive administration of a dose of 200mg/kg trichlorfon. RESULTS (mcg/g myocardial tissue): I day = 8, II day = 13.63, III day = 15, IV day = 18.96, V day = 19.6, VI day = 20.83, VII day = 21.21, VIII day = 21.33, IX day = 19.69, X day = 19.41.

Conclusions: An organophosphoric direct toxic mechanism is suggested, through accumulation over time of a certain level of myocardial concentration.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Chromatography, Gas
  • Death, Sudden, Cardiac / etiology*
  • Heart Diseases / chemically induced*
  • Heart Diseases / metabolism*
  • Insecticides / pharmacology*
  • Insecticides / toxicity
  • Male
  • Models, Animal
  • Myocardium / metabolism*
  • Rats
  • Rats, Wistar
  • Time Factors
  • Trichlorfon / pharmacokinetics*
  • Trichlorfon / toxicity

Substances

  • Insecticides
  • Trichlorfon