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1994 1
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Page 1
COVID-19-A Theory of Autoimmunity Against ACE-2 Explained.
McMillan P, Dexhiemer T, Neubig RR, Uhal BD. McMillan P, et al. Among authors: uhal bd. Front Immunol. 2021 Mar 23;12:582166. doi: 10.3389/fimmu.2021.582166. eCollection 2021. Front Immunol. 2021. PMID: 33833750 Free PMC article. Review.
Human lung myofibroblast-derived inducers of alveolar epithelial apoptosis identified as angiotensin peptides.
Wang R, Ramos C, Joshi I, Zagariya A, Pardo A, Selman M, Uhal BD. Wang R, et al. Among authors: uhal bd. Am J Physiol. 1999 Dec;277(6):L1158-64. doi: 10.1152/ajplung.1999.277.6.L1158. Am J Physiol. 1999. PMID: 10600886
Earlier work from this laboratory found that fibroblasts isolated from fibrotic human lung [human interstitial pulmonary fibrosis (HIPF)] secrete a soluble inducer(s) of apoptosis in alveolar epithelial cells (AECs) in vitro [B. D. Uhal, I. Joshi, A. True, S. Mundle, A. Ra …
Earlier work from this laboratory found that fibroblasts isolated from fibrotic human lung [human interstitial pulmonary fibrosis (HIPF)] se …
Fas-induced apoptosis of alveolar epithelial cells requires ANG II generation and receptor interaction.
Wang R, Zagariya A, Ang E, Ibarra-Sunga O, Uhal BD. Wang R, et al. Among authors: uhal bd. Am J Physiol. 1999 Dec;277(6):L1245-50. doi: 10.1152/ajplung.1999.277.6.L1245. Am J Physiol. 1999. PMID: 10600897
Recent works from this laboratory demonstrated potent inhibition of Fas-induced apoptosis in alveolar epithelial cells (AECs) by the angiotensin-converting enzyme (ACE) inhibitor captopril [B. D. Uhal, C. Gidea, R. Bargout, A. Bifero, O. Ibarra-Sunga, M. Papp, K. ...Ang, S …
Recent works from this laboratory demonstrated potent inhibition of Fas-induced apoptosis in alveolar epithelial cells (AECs) by the angiote …
Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung.
Uhal BD, Joshi I, Hughes WF, Ramos C, Pardo A, Selman M. Uhal BD, et al. Am J Physiol. 1998 Dec;275(6):L1192-9. doi: 10.1152/ajplung.1998.275.6.L1192. Am J Physiol. 1998. PMID: 9843857
Earlier work from this laboratory showed that abnormal fibroblast phenotypes isolated from fibrotic human lung produce factor(s) capable of inducing apoptosis and necrosis of alveolar epithelial cells in vitro [B. D. Uhal, I. Joshi, A. True, S. Mundle, A. Raza, A. Pardo, a …
Earlier work from this laboratory showed that abnormal fibroblast phenotypes isolated from fibrotic human lung produce factor(s) capable of …
Angiotensin II induces apoptosis in human and rat alveolar epithelial cells.
Wang R, Zagariya A, Ibarra-Sunga O, Gidea C, Ang E, Deshmukh S, Chaudhary G, Baraboutis J, Filippatos G, Uhal BD. Wang R, et al. Among authors: uhal bd. Am J Physiol. 1999 May;276(5):L885-9. doi: 10.1152/ajplung.1999.276.5.L885. Am J Physiol. 1999. PMID: 10330045
Recent work from this laboratory demonstrated potent inhibition of apoptosis in human alveolar epithelial cells (AECs) by the angiotensin-converting enzyme inhibitor captopril [B. D. Uhal, C. Gidea, R. Bargout, A. Bifero, O. Ibarra-Sunga, M. Papp, K. ...
Recent work from this laboratory demonstrated potent inhibition of apoptosis in human alveolar epithelial cells (AECs) by the angiotensin-co …
Essential role for cathepsin D in bleomycin-induced apoptosis of alveolar epithelial cells.
Li X, Rayford H, Shu R, Zhuang J, Uhal BD. Li X, et al. Among authors: uhal bd. Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L46-51. doi: 10.1152/ajplung.00442.2003. Epub 2004 Feb 20. Am J Physiol Lung Cell Mol Physiol. 2004. PMID: 14977632 Free article.
Am J Physiol Lung Cell Mol Physiol 284: L501-L507, 2003). Given the documented role of cathepsin D (CatD) in apoptosis of other cell types, we hypothesized that CatD might be the AEC enzyme responsible for the conversion of angiotensinogen into ANG I, the substrate for ACE …
Am J Physiol Lung Cell Mol Physiol 284: L501-L507, 2003). Given the documented role of cathepsin D (CatD) in apoptosis of other cell …
Cell cycle dependence of ACE-2 explains downregulation in idiopathic pulmonary fibrosis.
Uhal BD, Dang M, Dang V, Llatos R, Cano E, Abdul-Hafez A, Markey J, Piasecki CC, Molina-Molina M. Uhal BD, et al. Eur Respir J. 2013 Jul;42(1):198-210. doi: 10.1183/09031936.00015612. Epub 2012 Oct 25. Eur Respir J. 2013. PMID: 23100504 Free article.
Upregulation of the enzyme in cells that were progressing to quiescence was completely inhibited by the transcription blocker actinomycin D or by SP600125, an inhibitor of c-Jun N-terminal kinase (JNK). ...
Upregulation of the enzyme in cells that were progressing to quiescence was completely inhibited by the transcription blocker actinomycin …
Abrogation of ER stress-induced apoptosis of alveolar epithelial cells by angiotensin 1-7.
Uhal BD, Nguyen H, Dang M, Gopallawa I, Jiang J, Dang V, Ono S, Morimoto K. Uhal BD, et al. Am J Physiol Lung Cell Mol Physiol. 2013 Jul 1;305(1):L33-41. doi: 10.1152/ajplung.00001.2013. Epub 2013 Apr 26. Am J Physiol Lung Cell Mol Physiol. 2013. PMID: 23624786 Free PMC article.
ER stress was induced in A549 cells or primary cultures of human AECs with the proteasome inhibitor MG132 or the SP-C BRICHOS domain mutant G100S. ER stress activated the ANGII-generating enzyme cathepsin D and simultaneously decreased the ANGII-degrading enzyme ACE-2, whi …
ER stress was induced in A549 cells or primary cultures of human AECs with the proteasome inhibitor MG132 or the SP-C BRICHOS domain mutant …
The unfolded protein response controls ER stress-induced apoptosis of lung epithelial cells through angiotensin generation.
Nguyen H, Uhal BD. Nguyen H, et al. Among authors: uhal bd. Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L846-L854. doi: 10.1152/ajplung.00449.2015. Epub 2016 Sep 16. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27638906 Free PMC article.
The proteasome inhibitor MG132 or surfactant protein C (SP-C) BRICHOS domain mutation G100S induced apoptosis in human AECs by activating the proapoptotic cathepsin D and reducing antiapoptotic angiotensin converting enzyme-2 (ACE-2). ...The results showed that either MG13 …
The proteasome inhibitor MG132 or surfactant protein C (SP-C) BRICHOS domain mutation G100S induced apoptosis in human AECs by activating th …
16 results