Abstract
Introduction: ILD-GAP model has been shown to accurately predict mortality in major chronic ILD subtypes and at all stages of disease.
Aims: To see if the ILD-GAP model can predict mortality in our chronic ILD patients.
Methods: Case records of all new patients referred to a subspecialty interstitial lung disease clinic at Singapore General Hospital, a tertiary care university-affiliated teaching hospital, from May 12 to December 13 were interrogated.
Results: 53 new patients were screened and 9 were excluded – 7 did not have chronic ILD (1 acute hypersensitivity pneumonitis, 1 idiopathic pulmonary haemosiderosis, 2 lymphangioleiomyomatosis, 3 cryptogenic organising pneumonia) and 2 did not have pulmonary function tests. 44 patients were analysed - 9(20.5%) had IPF, 15(34.1%) had idiopathic NSIP, 16(36.4%) had CTD-ILD, 2(4.5%) had chronic hypersensitivity pneumonitis, and 2(4.5%) had unclassifiable disease. Mean(SD) age was 65(13.6)yr, 25(57%) male, and 27(61%) were never smokers. Mean(SD) FVC predicted was 62.3(15.4)%, and mean(SD) DLCO predicted was 51.1(14.5)%. 4 patients were lost to follow-up and excluded from further analysis. Only 1 patient fulfilled the ILD-GAP index of >5 and hence was not studied.
Our 1-year and 2-year mortality for ILD-GAP index 0-1, 2-3, and 4-5 was 0%, 7.7%, and 40%, and 16.7%, 25%, and 75% respectively.
Conclusions: In our cohort of patients mortalities were higher at each ILD-GAP index than the predicted 3.1%, 8.8%, and 18.2% for 1-year mortality, and 6.6%, 18%, and 35% for 2-year mortality. This could be due to our small sample size, and referrals to this subspecialized clinic were sicker patients at each ILD-GAP index. Further studies are needed to clarify our results.
- Copyright ©ERS 2015