Abstract
Rationale: U-BIOPRED aims to sub-phenotype SA through the life course of the disease, using an innovative systems biology approach
Methods: Children with SA and SPSW (defined in Thorax 2011;66:910) and mild-moderate controls were recruited. Data regarding demographics, exacerbations, quality of life (QoL), asthma control, lung function and FENO were collected.
Results: 272 children were enrolled. QoL scores were lowest in the SPSW cohort. They also had frequent exacerbations. Urinary cotinine was more often positive in children with SPSW compared to controls (20% vs 2.3% p=0.006) and their mothers were more likely to have smoked during pregnancy (13.8% vs 0% p=0.006).
Conclusions: These preliminary data confirm that severe paediatric cohorts have poor QOL despite significant treatment and are frequently exposed to tobacco smoke. There arevclear unmet needs in the management of these children. Integration of the clinical with high dimensional datasets will help to define sub-phenotypes.
- © 2014 ERS