Abstract
Introduction: The relationships between obstructive sleep apnea syndrome (OSAS) and cardiovascular risk factors are under wide-world interest.
The aim of the study was to analyze superoxide dysmutase-1 activity in erythrocytes of high risk for type 2 diabetes (pre-diabetic) males, due to a severity of OSAS diagnosis.
Methods: OSA suspected males with no acute or severe chronic disease were enrolled. Non-smoking Caucasians aged 30-63, with BMI 25-3,9 kg/m2, submitted clinical, biochemical and polysomnographic examinations. EMBLA device was used to establish the severity of apnea episodes. The results of oral glucose tolerance test allowed to select pre-diabetic males. Apnea/hypopnea index (AHI) categorized patients for: OSAS0 (n=14, aged 53±7, AHI 0-4,9), OSAS1 (n=14, aged 55±8, AHI 5-15); OSAS2 (n=14, aged 56±5, AHI 16-30); OSA3 (n=14, aged 55±7, AHI≥31). Plasma glucose, fasting lipid profile (T-C, HDL-C, LDL-C, TG), uric acid were estimated. Fasting serum insulin (ELISA BioSource, Sunrise Tekan) and erythrocyte Cu,Zn- superoxide dysmutase activity, SOD-1 (Randox, Statfax™ 1904 Plus) were determined. Statistical analysis was performed using STATISTICA 6.0 for Windows. Data are shown as means ± SD.
Results: 1.The studied groups did not differ in their age, BMI, blood pressure, and routine metabolic parameters.
2. Kruskal-Wallis Test revealed increased SOD-1 in OSAS1 group and the lowest in OSAS3 group (from OSAS0 to OSAS3: 1174±404 vs 1432±476 vs 1248±495 vs 944±298 U/gHGB; p=0,038).
Conclusion: In the studied pre-diabetic males only OSAS1 persons seem to present some native mechanisms for cardiovascular prevention.
- © 2011 ERS