Abstract
Introduction – objective: The aim of this study was to evaluate the effect of one night BPAP treatment on basal metabolism rate (BMR) of patients diagnosed with obesity hypoventilation syndrome (OHS).
Method: Basal metabolism rate of OHS patients who were newly diagnosed and hospitalized for PAP treatment was measured with indirect calorimetry before and after one night (at least 8 hours) PAP treatment. The values were compared and the effect of one night BPAP treatment on the BMR was determined.
Results: There were 11(%55) female and 9 (%45) male, totally 20 patients. The mean age was 57,9 ± 12,5 years and mean BMI was 51,2±9,2 kg/m2. Six of patients were active smokers, 14 were non smokers. There was a statistically significant decrease of BMR after BPAP therapy (p=0,014). There was no relationship between decrease of BMR and the demographic characteristics such as gender, smoking history and BMI. The decrease detected in VO2 levels after BPAP treatment was statistically significant (p=0,025). Lower VCO2 levels were measured after the BPAP treatment but it did not carry a statistical significance.
Conclusions: Short term use of BPAP treatment in OHS patient reduces the BMR and VO2 levels. This effect is probably seen as a result of the change in respiratory mechanics and workload by PAP therapy. Longer studies with more patients are needed to evaluate the effect of BPAP treatment on BMR.
- Copyright ©ERS 2015