Abstract
Target: To study outcomes of treatment with anti-TB drugs of the first and second lines and follow-up results in children and adolescents with TB.
Materials and methods: Comparative retrospective cohort study was conducted among 160 children and adolescents. Group I constituted from 80 patients treated with anti-TB of the second line and Group II from 80 patients treated with anti-TB drugs of the first line.
Results: Family contact with patients with MDRTB played the great role in 71.0% of patients in the Group I, while among patients of the Group II in 47.5%. Primary TB forms occurred more frequently among patients of the Group II (61.8%), secondary TB forms did among patients of the Group I (81.4%). Frequency of complications was also higher among patients of the Group I. So, bronchial TB was diagnosed in 63.0% and 11.2%, TB pleurisy in 35.0% and 11.2% relatively, hemoptysis, lung tissue destruction and atelectasis were observed in 26.0%, 2.0% and 9% of patients of the Group II. Processes with destruction were in 81.2% of patients of the Group I, and those of the Group II did in 28.2% only. Patients with positive smear were by 2 times more (62.3%) in the Group I than in the Group II (30.0%). MDR: in 100% of both groups culturally only. Thus, analysis of outcomes and follow-up control showed that among patients with MDR TB treated with drugs of the first line 5 (6.2%) patients of the Group II died, while among patients treated with DSL one adolescent only died. Relapse emerged in 12.5% of children and adolescents of the Group II. This fact proves the necessity to administrate the therapy with DSL to the children and adolescents with MDR TB.
- © 2012 ERS