Abstract
Background: Obstructive sleep apnea hypopnea is associated with obesity. Adipocytokines which were secretioned by fatty tissue can influence energy metabolism all over the body and development of obesity. Apelin, NPY and A-FABP were adipocytokines discovered for the past few years. They may participate the generation and development of OSHAS, especially obesity combined OSAHS.
Objective: To investigate the relationship between adipocytokines (Apelin, NPY and A-FABP) and obstructive sleep apnea-hyperpnoea syndrome (OSAHS).
Methods: Patients underwent polysomnography were recruited and divided into OSAHS group and non-OSAHS group. Each group was divided into obesity, hypergravity and normal body weight arms according BMI. OSAHS group was divided into mild, moderate and severe arms. Plasma Apelin, NPY, A-FABP (ng/ml) levels of all arms were tested and compared.
Results: Plasma adipocytokines Apelin, NPY and A-FAPB levels were significantly higher in OSAHS group than in the non-OSAHS group of same weight, independent of age and gender. These adipocytokines plasma levels were positively correlated with AHI, BMI, while negatively correlated with LSaO2 and MSaO2 in OSAHS group.
Conclusions: Obesity can cause the increase of plasma Apelin, NPY and A-FABP levels. These three adipocytokines were positively cforrelated with the severity degree of OSAHS.
- © 2011 ERS