Abstract
OBJECTIVES:Determining whether variations in time of use of quinolones:levofloxacin (LVF);and betalactamics (BTL): Penicillin (P),amoxicillin-clavulanic (AMC),imipenem(IMP) and ceftriaxone (CFT);have been parallel to variations in the sensitivity of the main respiratory pathogens.
METHODS:We studied 470 strains (sputum, bronchial aspirates, pleural and bronchoalveolar lavage) during 2006-2013, from patients with pneumonia.The bacterial resistance was determined by Minimum Inhibitory concentration (MIC), following recommendations of the Clinical and Laboratory Standars Institute.The use of antibiotics was obtained through the Hospital Pharmacy Service,using the Defined Daily Dose (DDDs) per 100 beds/day.
RESULTS:
1.BTL consumption showed a decline from 2011.However,with CFT was an increase from 2008.LVF remained constant.
2.Most isolates of S. pneumoniae were sensitive,without finding changes for BTL,except with AMC (in 2013).With H. influenzae were not variations,being sensitive to the two groups of antibiotics (94% and 93%).Regarding Pseudomonas spp.was a decline in sensitive isolates from 2009.Prevalence for LVF remains, being more sensitive to them than againts BTL. M. catarrhalis showed no changes.
3.The decline in the consumption of BTL from 2011 was not accompanied by a parallel increase of LVF.
CONCLUSIONS: Betalactamics consumption in our hospital for the treatment of community acquired pneumonia, remains higher than levofloxacin.However the percentage of isolates sensitive to that antibiotic comes to be superior in some of the microorganisms tested.That is why levofloxacin is an effective alternative to betalactamics in the treatment of pneumonia.
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