Abstract
Aim and Object: To evaluate the prevalence of pre-extensively drug resistant tuberculosis (Pre-XDR), extensively drug resistant tuberculosis (XDR) among the MDR TB patients.
Material & Method: We reviewed the record of all patients registered in MDR clinic of Ojha Institute of Chest Diseases between January 2010 and December 2014. Data was collected about clinical details and resistance pattern.
Results: A total of 919 patients were enrolled during the period. 465(51%) were male. Most of the patients (718/919) were young i.e. from 15-44 age group. The pre-XDR TB and XDR-TB prevalence rate among MDR TB patients were 363/919 (39.5%) and 18/919 (02%) respectively. Out of 18 XDR-TB patients 05 were resistant to Km(Kanamycin) Am(Amikacin) Cm(Capreomycin) FQ (Fluoquinolone), 04 were resistant to Km + FQ, 03 against Am+FQ and 06 against Cm+FQ. Out of 363 Pre-XDR TB patients 332 were resistant to FQ, 04 to Km, 07 to Cm, 02 were resistant to Km + Am and 18 were resistant to Km Am Cm.
Conclusion: There is high prevalence of pre-XDR tuberculosis in patients registered at Ojha Institute of Chest Diseases, Karachi, Pakistan. The XDR- TB cases are also reported and registered. There is a need to closely follow the new TB patients registered in chest clinics for proper treatment and compliance to prevent drug resistant tuberculosis. There is also a need to ban over the counter sale of ATT and specifically quinolones.
- Copyright ©ERS 2015