Abstract
Objectives: Analyze the patterns of recurrence and survival in lung cancer patients underwent surgery
Material and methods: Observational, retrospective cohort of lung cancer patients undergoing surgery during years 1999-2006 in CHOU-Spain. We performed a descriptive analysis of data, the continuous variables to be non-Gaussian are shown as median and categorical variables as frequencies and percentages. We determined the clinical factors associated with recurrence and survival by Kaplan-Meier curves and Cox regressions models. We used SPSS 15.0 software
Results: 168 patients underwent surgery, of whom 79.8% were men, and the median age was 67 years [35-82], 74 ex-smokers (44%) and 63 active smokers (37.5%). Most common histological type was epidermoid 88 (52.4%) followed by adenocarcinoma 48 (28.6%). The median tumor size in CM was 3.3 [0-9], and moderate degree of differentiation in 77 (45.8%). The pathological stages were: I 91 (57.6%), II 26 (16.5%), IIIA 30 (19%), IIIB 11 (6.5%). The most frequent surgical resection was lobectomy. Recurrence occurred in 78 (46%) patients, related with tumor size (p = 0.002) and pathological stage (p <0.001), no differences in the histological subtype (p = 0.232). Coughing and CNS disorders were the most prevalent symptoms of recurrence and extrathoracic involvement was in 42 cases (58.3%). The median survival in those who had recurrence was 9 months, with 95% CI [5.129 to 12.871]. Other risk factors of death were tumor size (p = 0.002) and pathological stage (p <0.001)
Conclusions: Most patients do not relapse. Recurrence was more frequent extrathoracic location. The tumor size and advanced stages determine higher risk of recurrence and mortality.
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