Abstract
Objective
To describe the results of the use of IC in patients with non-cystic fibrosis(CF)bronchiectasis colonized by Pseudomonas aeruginosa in terms of efficiency and quality of life(QOL)
Material and Method
Retrospective observational study.Patients who started treatment with IC within a period of 4 years were selected.For each patient we collected demographic,clinical and microbiological data evaluating whether the colonization was initial,intermittent or chronic.At the end of the treatment,efficacy was determined by examining the negative cultures and QOL according to the use of antibiotics and hospitalizations pre and post treatment as well as the adverse effects
Results
58 patients who began treatment with IC with an average age of 70±15,4 years were included,43,1% were women.Regarding the type of colonization in 20 patients was initial,in 5 was intermittent and in 24 was chronic.At the time of data collection,32 patients had completed the treatment of which 11 defaulted(9 by adverse reactions and 2 for difficulty in handling the device).The average duration of treatment was 4,5±4 months and 17 negativized the cultures(9 with initial colonization,1 with intermittent and 7 with chronic).The average number of admissions before treatment was 2,5±2,2 versus 0,6±0,9 post-treatment.The average number of antibiotics that took previously to IC was 4,4±3,8 being 1,3±1,6 post-treatment
Conclusions
The proportion of patients who negativized cultures with initial colonization is relevant(45%),thus concluding that early initiation improves efficiency
The reduction of antibiotic use and hospital admissions along with few adverse reactions,demonstrate the improvement in QOL of patients.
- © 2014 ERS