Abstract
Leptin is a hormone secreted by adipocytes, with a variety of physiological activities including control of metabolism,energy homeostasis,neuroendocrine regulation,activation of the immune system. Aim: the aim of the study was to explore possible relationships between serum concentration of leptin and selected proinflammatory cytokines in patients with sarcoidosis(pts).
Methods: 40 pts(22M 18F) mean age 45y±11.5y, were enrolled in to the study. Mean time of observation was 5.6±5.0y. Blood samples were collected in the morning and stored at -80°C until assayed. Serum leptin(sL), tumour necrosis factor(TNF-α), interleukin(IL)-1ß,5,6 and C-reactive protein(CRP) were quantified. Bioelectrical impedance was used to measure fat-free mass(FFM),fat mass(FM) using a Bodystat 1500 and the FFMI(fat-free mass index) was defined.
Results: on average male subjects showed lower level of sL (7.03±5.07 ng/ml) compared with females (28.7±38.5ng/ml) which is explained by the different distribution of adipose tissue. Statistically significant correlation (p<0.0001) between sL and FM among men and weak correlation between sL and FFMI among men and sL and FM in women was found. There was no correlation between sL and serum concentrations of CRP,TNF-α, IL-5,6. The statistically significant (p<0.001) correlations were found: between serum concentrations of CRP and TNF-α and CRP and IL-6 and TFN-α and IL-6 for whole group and among men, also between TNF-α and IL-6 among women.
Conclusions: our findings could support the role of CRP as a biomarker among sarcoid patients but does not support correlation between sL and TNF-α, IL-5 and 6 in the studied group. All these findings need to be verified with large-scale studies.
- Copyright ©ERS 2015