Abstract
LCI is a robust measure of ventilation distribution in CF. There are no data demonstrating a relationship between LCI and biomarkers of systemic inflammation during clinical stability.
Objective: To investigate the relationship between C-reactive protein, (CRP), White Cell Count (WCC) and LCI in CF. Methods: Stable CF patients from Northern Ireland CF centres, aged ≥ 6 years were recruited. LCI was derived from multiple breath washout. Blood CRP and WCC were measured by turbidimetric immunoassay. Spearman correlation coefficient was used. Results: n=83 (table 1).
CRP (figure 1) and WCC (figure 2) had a significant correlation with LCI. Similarly, there was a significant correlation between CRP (r=-0.37; p=0.0006),WCC (r=-0.47; p<0.0001) and FEV1% pred.
Conclusion: Increased systemic inflammation in CF is associated with deterioration in LCI.
Funder: US-Ireland Project Partnership Grant.
- © 2014 ERS