Abstract
Background: MRD therapy may improve BP in OSA pts with arterial hypertension (HTN).
Aims: ORCADES, a French prospective multicenter cohort study is evaluating the long-term effects of a custom-made MRD in OSA pts who refused or did not tolerate CPAP. Interim data are presented at 3-month follow-up.
Methods: Clinical benefits and side effects are evaluated in OSA pts fitted with a CAD/CAM MRD (Narval CC™). Patient was hypertensive (HTN) if office systolic and/or diastolic BP were respectively ≥140 and ≥90 mmHg.
Results: 77 HTN and 222 non-HTN pts treated with MRD were analysed. Sex ratio (75% male), age (53±11y) and AHI (29±15/h) were similar in both groups. In HTN group, body mass index was higher and nadir SpO2 was lower.
Therapy success (AHI reduction ≥50%) was higher in non-HTN group (84% vs. 66%, p=0.0012). Improvement in oxygen saturation, sleepiness or quality of life was equivalent in both groups with no weight change. In HTN group, SBP and DBP were reduced significantly and BP was normalized in 59% of pts. SBP decrease was correlated with mean SpO2 improvement (ρ=-0.30, p=0.022).
Only 8% of pts stopped MRD due to side effects and mean usage was similar in both groups (6.7 hours/night).
Conclusion: Custom-made CAD/CAM MRD is effective in OSA pts noncompliant with CPAP with additional benefits on blood pressure.
- Copyright ©ERS 2015