Abstract
Objective: The incidence of tuberculosis (TB) in Pakistan is 340 per 100,000 but information about geographical prevalence, transmission, evolutionary genetics and drug resistance of M. tuberculosis strains remain limited. The major problem faced by the TB control authorities globally is the emergence of multidrug resistant TB and extensively drug resistant TB.
Methods: A total of 268 MDR-TB/XDR-TB strains collected from different regions of Pakistan. Species identification was done by standard mycobacteriological procedures and DST was performed by proportion method. PCR analysis of IS6110, Beijing and non-Beijing family was evaluated.
Results: Samples were taken from 6 major cities. Male to female ratio was 41:59 respectively with mean age 37 DST pattern was noted region wise. 90% strains were resistant to all first line drugs 7 XDR-TB strains were found. 91% strains belong to non Beijing family.
Age groups | No. of Ptients |
10-14 | 4 |
15-19 | 32 |
20-24 | 49 |
25-29 | 46 |
30-34 | 42 |
35-39 | 30 |
40-44 | 20 |
45-49 | 18 |
50-54 | 10 |
55-59 | 5 |
60-64 | 7 |
65-69 | 2 |
70-74 | 2 |
75-79 | 2 |
80-84 | 1 |
Antibiotic Drugs | No. Of Patients resistant for Drugs | No. Of Patient sensitive for Drugs |
Streptomycin | 184 | 84 |
Isoniazid | 262 | 6 |
Rifampicin | 254 | 14 |
Pyrazinamide | 167 | 101 |
Ethinamide | 40 | 228 |
Kanamycin | 25 | 243 |
Amikacin | 10 | 240 |
Ofloxacin | 157 | 110 |
Capreomycin | 9 | 222 |
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