Abstract
Pulmonary function tests are important to determine the severity of cystic fibrosis (CF) and to predict prognosis. We aimed to evaluate the pulmonary function of CF children with impulse oscillometry (IOS), analyze the correlation of IOS and spirometry results and evaluate the ability of IOS to detect pulmonary function abnormality at acute exacerbations. CF children aged 3-18 year old and healthy controls were enrolled to the study. IOS was performed by all patients and spirometry was performed by 17 patients who could perform it; three times during stable period and at the time of acute exacerbations. Ninety-four children (49 CF patients, 45 healthy controls) were enrolled to the study. Resistance results at all frequencies (R5-20), impedance (Z5), resonance frequency (Fres) and reactance area (AX) results were higher while reactance results (X5-20) were lower than those of the control group. Patients evaluated during exacerbation had higher R5, R10, R15, R20, Z5, Fres and AX but lower X5, X10, X15, X20 results. There was a statistically significant difference between measurements at exacerbation and during stable period at all parameters. FEV1 correlated with R5, R10, X5, X10, X15, Fres, Z5 and AX, FVC correlated with X10, X15, Fres, and AX and FEV1/FVC correlated with R5, X15, Fres, Z5, and AX results. FEF25-75 correlated with all parameters except R15 and R20. IOS was able to detect the lung function abnormalities of CF patients and the deterioration during acute excerbations. Especially; X15, Fres, and AX had significant correlation with FEV1, FVC, FEV1/FVC and FEF25-75.
- Copyright ©ERS 2015