Abstract
Introduction: In this study, we aimed to assess relationship between disease severity and lipid profile and the role of gender and obesity in this relationship in patients with OSA.
Material Method: We retrospectively reviewed records of 699 patients, who presented to Sleep Laboratory. After exclusion criteria, overall 187 cases were included to the study and two groups were formed ( AHI<15 and AHI ≥15).
Results: Average level of TG (Triglycerides), Cholesterol and LDL were higher and HDL was lower in AHI ≥15 group than AHI<15 group in all cases. Average level of Cholesterol was higher in AHI ≥15 group than AHI<15 group in males and this difference was statistically significant (p=0,037). Average level of TG was higher in AHI ≥15 group than AHI<15 group in BMI<30 cases and this difference was statistically significant (p=0,03). Average level of HDL was lower in AHI ≥15 group than AHI<15 group in BMI ≥30 cases and this difference was statistically significant(p=0,015). There was a negative correlation between sleep efficacy and level of LDL in all cases (r=-0,184, p=0,04). There was a positive correlation between AHI and level of TG in BMI< 30 cases (r=0,255 p=0,022). There was a positive correlation between AHI and level of cholesterol in BMI< 30 male cases (r=0,309, p=0,012). Avarege level of neck circumference, waist circumference, weight and BMI was significantly higher in AHI ≥15 than AHI<15 group.
Conclusion: It is observed that the negative effects of disease severity on lipid profile. According to the our results, gender and obesity may have a role on lipid profile in OSA patients, and especially in male gender, OSA may have a negative effect on lipid profile independently with obesity.
- Copyright ©ERS 2015